Assistant Professor, Department of BiochemistryTumor Cell Biology ProgramPhD, Biomedical Sciences, 2002, University of Chile, Santiago, ChilePostdoctoral fellow, 2002-04, University of Chile, Santiago, ChilePostdoctoral fellow, 2004-08, Northwestern University, Evanston, ILProfessional Associate in Research, 2008-11, Mayo Clinic, Rochester, MN
Contact information2500 N State St, Room G760Jackson, MS 39216Phone: (601) 815-3511E-mail: firstname.lastname@example.org
Progression of cancer is linked to the expression of myriad proteins; among them, angiogenic factors that induce blood vessel formation and tumor growth play an important role. In breast cancer, the pro-angiogenic factor Cyr61 is expressed in about 30% of highly aggressive triple negative breast carcinomas and is also expressed in a subpopulation of Estrogen Receptor positive (ER+) breast carcinomas. In ER+ breast tumors it induces estrogen independence and anti-estrogen resistance. We have shown that the interaction of Cyr61 and integrin receptors generates differential response to chemotherapeutic drugs. These studies have put in the map Cyr61 as a potential target for breast cancer. Based on these results, an ongoing clinical trial blocking Cyr61/αvβ3 integrin interaction in cancer patients has been opened.
Currently I am focused in studying the role of Notch signaling in ER+ breast carcinomas. Dr. Miele's work has demonstrated that in ER+ breast cancer cells Notch signaling is inhibited by Estrogen and reactivated by 4-OH-Tamoxifen. It increases the cell dependence on Notch signaling for survival. In vivo studies using xenografts models, showed that Tamoxifen and a pharmacological Notch inhibitor (γ-secretase inhibitor, GSI) caused tumor regression. Based on these data a pilot clinical trial using a combination regimen including endocrine therapy (Letrozole or Tamoxifen) and GSI is currently underway. The goal of these studies is to define new targeted therapies for ER+ breast cancer patients that have developed resistance to endocrine therapy.
2500 North State Street
Jackson, MS 39216
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