Assistant ProfessorTumor Cell Biology ProgramMD, Medicine, 1983, Medical School, Xi'an Jiaotong University, Xi'an, ChinaPostdoc, 1990-91, Kyoto Prefectural University of Medicine, Kyoto, Japan
Contact Information2500 N State St., Room G762Jackson, MS 39216Phone: (601) 815-3094Email: email@example.com
Research synopsisNotch signaling pathway plays a critical role in the development and homeostasis of tissue by regulation cell-fate decision, proliferation, differentiation and apoptosis. Dysregulated activity of Notch signaling is often associated with tumorigenesis. Up-regulated expression of Notch receptors and their ligands has been reported in numerous solid and some hematopoietic malignancies. Moreover, a number of studies have suggested an involvement of Notch signaling in cancer angiogenesis and metastasis. We are interested in (1) Evaluating the expression and subcellular localization of Notch receptors/ligands and their associations with clinical outcome and tumor clinicopathological parameters in human malignancies, especially in breast cancer and prostate cancer using IHC analysis on TMAs constructed from human cancer tissue specimens; (2) Performing correlative and biomarker studies in tissue specimens from biopsies of cancer patients enrolled in the clinical trials in which Notch inhibitor in combination with other anti-cancer compounds was tested. In addition, the studies from our research group have revealed that IKKα and its kinase activity are required by Notch-1 for transcriptional activity of ER-dependent genes. The finding suggests that promoting the chromatin recruitment of IKKα is a novel function of Notch-1, through which Notch-1 can mediate crosstalk with other transcription factors. It is well known that Akt phosphorylates numerous protein targets that control cell survival, proliferation and motility. So far many studies have demonstrated the involvement of Akt signaling in Notch activation. The illustration of possible role of Akt signaling in the Notch-1 mediated ER-dependent transcription via IKKα in breast cancer cells will be of significantly importance, which will greatly benefit our understanding of the mechanism whereby Notch signaling exerts its function in tumourigenesis.
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