Cancer Institute

  • He Zhu

    zhu_he.jpgAssistant Professor
    Tumor Cell Biology Program
    MD, Medicine, 1983, Medical School, Xi'an Jiaotong University, Xi'an, China
    Postdoc, 1990-91, Kyoto Prefectural University of Medicine, Kyoto, Japan

    Contact Information
    2500 N State St., Room G762
    Jackson, MS 39216
    Phone: (601) 815-3094
    Email: hzhu2@umc.edu

    Research interests

    • Expression and subcellular localization of Notch receptors and their ligands and their association with clinical outcome and tumor clinicopathological parameters in human malignancies.
    • Role of Akt signaling in the Notch-1 mediated ER-dependent transcription via IKKa in breast cancer cells 

    Research synopsis
    Notch signaling pathway plays a critical role in the development and homeostasis of tissue by regulation cell-fate decision, proliferation, differentiation and apoptosis. Dysregulated activity of Notch signaling is often associated with tumorigenesis. Up-regulated expression of Notch receptors and their ligands has been reported in numerous solid and some hematopoietic malignancies. Moreover, a number of studies have suggested an involvement of Notch signaling in cancer angiogenesis and metastasis. We are interested in (1) Evaluating the expression and subcellular localization of Notch receptors/ligands and their associations with clinical outcome and tumor clinicopathological parameters in human malignancies, especially in breast cancer and prostate cancer using IHC analysis on TMAs constructed from human cancer tissue specimens; (2) Performing correlative and biomarker studies in tissue specimens from biopsies of cancer patients enrolled in the clinical trials in which Notch inhibitor in combination with other anti-cancer compounds was tested.  In addition, the studies from our research group have revealed that IKKα and its kinase activity are required by Notch-1 for transcriptional activity of ER-dependent genes. The finding suggests that promoting the chromatin recruitment of IKKα is a novel function of Notch-1, through which Notch-1 can mediate crosstalk with other transcription factors. It is well known that Akt phosphorylates numerous protein targets that control cell survival, proliferation and motility. So far many studies have demonstrated the involvement of Akt signaling in Notch activation. The illustration of possible role of Akt signaling in the Notch-1 mediated ER-dependent transcription via IKKα in breast cancer cells will be of significantly importance, which will greatly benefit our understanding of the mechanism whereby Notch signaling exerts its function in tumourigenesis.

    Selected publications

    • Zhu H et al.Elevated Jagged-1 and Notch-1 expression in high grade and metastatic prostate cancers.  Am J Transl Res 2013;5(3):xxx-xxx ( in press).
    • Zhu H et al. Correlation of Notch1, pAKT and nuclear NF-κB expression in triple negative breast cancer. Am J Cancer Res 2013;3(2):230-239.(http://ajcr.us/files/ajcr0000176.pdf)
    • Zhu H et al. Cross-reactivity of rabbit anti-bovine prothrombin/thrombin IgGs with bovine factor V/Va-related antigens. Clin Appl Thromb Hemost 16(5):522-28, 2010.  (http://www.ncbi.nlm.nih.gov/pubmed/20699260 )
    • Zhu H et al.  Reduced immunogenic potential of membrane filtered bovine thrombin preparations for hemostatic application.  Clin Appl Thromb Hemost 15(1):32-40, 2009. ( http://www.ncbi.nlm.nih.gov/pubmed/18977777 )
    • Zhu H et al. Normal [3H]flunitrazepam binding to GABAA receptors in the locus coeruleus in major depression and suicide. Brain Res 1125:138-46, 2006. (http://www.ncbi.nlm.nih.gov/pubmed/17118347)
    • Zhu Hand Piletz J.   Association between I2 binding sites and monoamine oxidase-B activity in platelets. Ann. N.Y. Acad. Sci. 1009: 347-352, 2003. (http://www.ncbi.nlm.nih.gov/pubmed/15028609)
    • Zhu H et al.  Atypical [3H]Clonidine binding sites in human caudate and platelets on cryostat-cut sections. Ann. N.Y. Acad. Sci.  1009: 296-301, 2003. (http://www.ncbi.nlm.nih.gov/pubmed/15028603)
    • Zhu H et al. Non-adrenergic exploratory behavior induced by moxonidine at mildly hypotensive doses. Brain Res 964(1): 9-20, 2003. (http://www.ncbi.nlm.nih.gov/pubmed/12573508)
    • Zhu H et al. Effect of bupropion on immunodensity of putative imidazoline receptors on platelets of depressed patients.  J Psychiatric Res 33: 323-33, 1999. (http://www.ncbi.nlm.nih.gov/pubmed/10404470)
    • Zhu H et al. Chronic imipramine treatment upregulates IR2-imidazoline receptive sites in rat brain. Neurochem Int  30(1): 101-107, 1997. (http://www.ncbi.nlm.nih.gov/pubmed/9116580)