Cancer Institute

  • Gene L. Bidwell III

    bidwell_gene.jpgAssistant Professor
    Molecular Cancer Therapeutics
    PhD., Biochemistry, 2007, University of Mississippi Medical Center, Jackson, MS
    Postdoctoral Fellowship, 2007-10, University of Mississippi Medical Center, Jackson, MS

    Contact information
    Department of Neurology
    2500 N State St., Room N321-2
    Jackson, MS 39216
    Phone: (601) 984-6787

    Research interests

    • Targeted drug delivery
    • Therapeutic peptides
    • Breast cancer, glioblastoma, pregnancy

    Research synopsis

    My research interests include targeted drug delivery, developmental cancer therapeutics and therapeutic peptides and proteins. My background and training included the development of stimulus-responsive drug carriers for targeting drugs to solid tumors. We utilized a thermally responsive carrier to target therapeutic peptides and small molecule chemotherapeutics to tumor sites using focused heating. My current research interests include developing novel nanoparticle platforms for delivery of peptide, protein and siRNA – based therapeutics.

    Peptides and siRNA have great potential as therapeutic agents due to their ease of design and high specificity for their targets. However, their usefulness as drugs is limited by their poor performance in the body, including rapid degradation and poor tumor penetration. We are working to develop carriers for peptide and siRNA drugs that can overcome these limitations and make these agents effective for cancer therapy.

    We are also interested in drug delivery during pregnancy. We are developing carriers that can be fused to therapeutic agents, including chemotherapeutics and peptides, that prevent them from crossing the placenta and reaching the baby. Our goal is to develop a means to treat disorders of pregnancy (such as preeclampsia), or to deliver cancer chemotherapy, to pregnant patients without risking harm to the developing fetus from drug exposure.

    Recent accomplishments and honors

    • 2011 - Department of Defense Breast Cancer Research Program Era of Hope Conference Distinguished Postdoctoral Poster Award
    • 2010 - American Association for Cancer Research - Sanofi-Aventis Scholar-in-training Award
    • 2009 - University of Mississippi Medical Center Excellence in Research Award - Bronze Medal

    Selected publications

    • Bidwell, G. L. 3rd, Perkins, E., Hughes, J. D., Khan, M., James, J. R.,and Raucher, D.  Thermally Targeted Delivery of a c-Myc Inhibitory Polypeptide Inhibits Tumor Progression and Extends Survival in a Rat Glioma Model.  PLoS One, 8(1), 2013.  PubMed link Full text open access link      
    •  George, E. M. and Bidwell, G. L. 3rd. STOX1: A new player in preeclampsia?  Hypertension, 61(3): 561-3.  2013.  PubMed link 
    • Bidwell, G. L. 3rd.  Peptides for Cancer Therapy – A Drug Development Opportunity and a Drug Delivery Challenge.  Therapeutic Delivery.  3(5): 609-21.  2012.  PubMed link 
    • Bidwell, G. L. 3rd, Perkins, E.,and Raucher, D.  A thermally targeted c-Myc inhibitory polypeptide inhibits breast tumor growth.  Cancer Letters. 28;319(2):136-43, 2012.  PubMed linkfull text
    • Bidwell, G. L. 3rd and Raucher, D.  Cell penetrating elastin-like polypeptides for therapeutic peptide delivery.  Advanced Drug Delivery Reviews.  30;62(15):1486-96, 2010.  PubMed link. Full text in PMC
    • Bidwell, G. L. 3rd and Raucher, D.  Therapeutic Peptides for Cancer Therapy:  Part I – Peptide Inhibitors of Signal Transduction Cascades.  Expert Opinion on Drug Delivery. 6(10):1033-47, 2009.  PubMed link 
    • Raucher, D., Moktan, S., Massodi, I., and Bidwell, G. L. 3rd.  Therapeutic Peptides for Cancer Therapy:  Part II – Cell Cycle Inhibitory Peptides and Apoptosis Inducing Peptides.  Expert Opinion on Drug Delivery.  6(10):1049-64, 2009.  PubMed link 
    • Bidwell, G. L. 3rd,Davis, A.N., and Raucher, D.  Targeting a c-Myc Inhibitory Polypeptide to Specific Intracellular Compartments using Cell Penetrating Peptides.  J. Control. Release.  135(1):2-10, 2009.  PubMed link. Full text link   
    • Bidwell, G. L. 3rd,Fokt, I., Priebe, W., and Raucher, D. Development of Elastin-like polypeptide for thermally-targeted delivery of doxorubicin. Biochem. Pharmacol. 73(5):620-31, 2007.  PubMed link.
    • Bidwell, G. L. 3rd and Raucher, D. Application of thermally responsive polypeptides directed against c-Myc transcriptional function for cancer therapy. Mol. Cancer Ther, 4: 1076-1085, 2005.  PubMed link. Full text