Cancer Institute

  • Chindo Hicks

    hicks_chindo.jpgAssociate Professor, Department of Medicine
    Director, Cancer Bioinformatics Core
    Member, Cancer Genetics Program

    PhD, Statistical Genetics 1995, University of Copenhagen, Denmark

    Contact information
    2500 N State St.
    Cancer Institute, Room G659
    Arthur Guyton Research Center
    Jackson, MS 39216
    Phone: (601) 815-6829

    Research interests

    • Integrative bioinformatics approaches to biomarkers discovery in cancer and other common human diseases
    • Computational and population genomics of cancer and other common human diseases
    • Pathway prediction, modeling gene-gene and protein-protein interactions, and characterization of gene and protein functions

    Research synopsis

    The broad goal of our research is to dissect the genetic architecture of cancer and other common human diseases such as obesity, diabetes etc. We develop and apply integrative bioinformatics and computational genomics approaches to analysis of high-through "omics", genotype and sequence data. We are particularly focused on biomarker discovery and functional genomics problems involving high-dimensional data sets, such as that obtained from whole genome-transcription profiling, proteomics, large-scale genotyping, and next generation sequencing. The overarching goal of our research is to utilize multiple sources of high-throughput "omics" data to understand the molecular and genetic basis of cancer and other common human diseases and to integrate these data with clinical information to improve human health and reduce health disparities. This involves modeling the complex biological machinery, characterizing the "wiring" diagrams or biological pathways, and elucidating the functional effects of genetic variants, indels, and copy number variants on cis regulatory elements and ncRNAs such as miRNAs.

    Selected publications

    • Churbanov A, Vorechovský I, Hicks C. Computational prediction of splicing regulatory elements shared by Tetrapoda organisms. BMC Genomics. 2009 Nov 4;10:508. PMCID: PMC2777938.
    • Churbanov A, Vorechovský I, Hicks C. A method of predicting changes in human gene splicing induced by genetic variants in context of cis-acting elements. BMC Bioinformatics. 2010 Jan 12;11:22. PMID: 20067640.
    • Gerds A, Fox-Geiman M, Dawravoo K, Rodriguez T, Toor A, Smith S, Kiley K, Fletcher-Gonzalez D, Hicks C, Stiff P. Randomized phase III trial of pegfilgrastim vs. filgrastim after autologous peripheral blood stem cell transplantation. Biol Blood Marrow Transplant. 2010 May;16(5):678-85. PMID: 20045479.
    • Hicks C, Pannuti A and Miele L. Associating GWAS information with the Notch signaling pathway using transcription profiling. Cancer Informatics. 2011; 10:93-108.
    • Hicks C, Pannuti A and Miele L. An Integrative genomics approach to biomarker discovery in breast cancer. Cancer Informatics, 2011; 10:185-204.