• Current Obesity Research

     Recently published scientific articles and book chapters on obesity-related studies by UMMC faculty include:

    1. Baker RC, Nikitina Y, Subauste AR. Analysis of adipose lipid using mass spectrometry. Methods Enzymol.  2014;538:89-105.
    2. Bassi M, Furuya WI, Menani JV, Colombari DS, do Carmo JM, daSilva AA, Hall JE, Moreira TS, Wenker IC, Mulkey DK, Colombari E.  Leptin into the ventrolateral medulla facilitates chemorespiratory response in leptin-deficient (ob/ob) mice. Acta Physiol(Oxf). 2014; 211:240-248.
    3. Bergin PF, Knelp C, Pierce C, Hendrix ST, Porter SE, Graves ML,Russell GV. Modifier 22 for acetabular fractures in morbidly obese patients: does it affect reimbursement? Clin Orthop Relat Res. 2014 Apr 29.
    4. Chade AR, Stewart NJ, Peavy PR. Disparate effects of single endothelin A and B receptor blocker therapy on the progression of renal injury in advanced renovascular disease. Kidney Int. 2014; 85:833-844. PMCID: PMC3972340
    5. de Castro Brás LE, Cates C, DeLeon-Pennell KY, Ma Y, Halade GV,Yabluchanskiy A, Fields GB, Weintraub ST, Lindsey ML. Citrate synthase is a novel in vivo matrix metalloproteinase-9 substrate that regulates mitochondrial function in the post-myocardial infarction left ventricle. Antioxid Redox Signal. 2014 Feb 19.
    6. da Silva AA, do Carmo JM, Wang Z, Hall JE.  The brain melanocortin system, sympathetic control, and obesity hypertension.  Physiology.  2014;29:196-202.  PMID:24789984
    7. Hall ME, do Carmo JM, da Silva AA, Juncos LA, Wang Z, HallJE.  Obesity, hypertension, and chronic kidney disease. Int J Nephrol Renovasc Dis. 2014; 7:75-88. PMCID:PMC3933708
    8. Henegar JR, Zhang Y, Rama RD, Hata C, Hall ME, Hall JE.  Catheter-based radiorefrequency renal denervation lowers blood pressure in obese hypertensive dogs. Am J Hypertens. 2014 Apr 6. doi: 10.1093/ajh/hpu048. [Epub ahead of print]. PMID:24709437
    9. Hosick PA, AlAmodi AA, Storm MV, Gousset MU, Pruett BE, Gray W 3rd, Stout J, Stec DE. Chronic carbon monoxide treatment attenuates development of obesity and remodels adipocytes in mice fed a high-fat diet. Int J Obes (Lond). 2014;38:132-139.
    10. Intapad S, Ojeda NB, Dasinger JH, Alexander BT. Sex differences in the developmental origins of cardiovascular disease. Physiology (Bethesda). 2014; 122-132. PMCID:PMC3949204
    11. Ma Y, Yabluchanskiy A, Hall ME, Lindsey ML. Using plasma matrix metalloproteinase-9 and monocyte chemoattractant protein-1 to predict future cardiovascular events in subjects with carotid atherosclerosis. Atherosclerosis. 2014; 232:231-233.
    12. Maranon RO, Lima R, Mathbout M, do Carmo JM, Hall JE, Reckelhoff JF. Postmenopausal hypertension: role of the sympathetic nervous system in an animal model. Am J Physiol Regu Integr Comp Physiol. 2014; 306:R248:R256. PMCID: PMC3921310
    13. Pan H, Qin K, Guo Z, Ma Y, April C, Gao X, Andrews TG, Bokov A,Zhang J, Chen Y, Weintraub ST, Fan JB, Wang D, Hu Y, Aune GJ, Lindsey ML, Li R. Negative elongation factor controls energy homeostasis in cardiomyocytes. Cell Rep. 2014;7:79-85.
    14. Toba H, Cortez D, Lindsey ML, Chilton RJ. Applications of miRNATechnology for Atherosclerosis. Curr Atheroscler Rep. 2014; 16:386.
    15. Xiang L, Lu S, Mittwede PN, Clemmer JS, Hester RL. Inhibition of NADPH oxidase prevents acute lung injury in obese rats following severe trauma.  Am J Physiol Heart Circ Physiol. 2014; 306:H684-H689. PMCID: PMC3949061
    16. Alexander BT, Intapad S. Activation of the sympathetic nervous system, is it the key to the developmental origins of enhanced cardiovascular risk? Am J Physiol Renal Physiol. 2013;305:F641-F642. PMCID: PMC3761202
    17. Chade AR. Renal Vascular Structure and Rarefaction. Compr Physiol. 2013; 3:817-831. PMCID: PMC3936257
    18. Chade AR, Stewart N. Angiogenic Cytokines in renovascular disease: Do they have potential for therapeutic use? J Am Soc Hypertens. 2013; 7:180-190. PMCID: PMC3605220
    19. da Silva AA, do Carmo JM, Hall JE. Role of leptin and central nervous system melanocortins in obesity hypertension. Curr Opin Nephrol Hypertens. 2013: 22:135-140. PMCID: PMC3905446
    20. do Carmo JM, da Silva AA, Sessums PO, Ebaady SH, Pace BR,Rushing JS, Davis MT, Hall JE. Role of Shp2 in forebrain neurons in regulating metabolic and cardiovascular functions and responses to leptin. Int J Obes (Lond). 2013; doi:10.1038/ijo.2013.177. PMCID: PMC3954949
    21. do Carmo JM, da Silva AA, Dubinion J, Sessums PO, Ebaady SH,Wang Z, Hall JE. Control of metabolic and cardiovascular function by the leptin-brain melanocortin pathway. IUBMB Life. 2013; 65:692-698.
    22. do Carmo JM, da Silva AA, Rushing JS, Pace B, Hall JE.  Differential control of metabolic and cardiovascular functions by melanocortin-4 receptors in proopiomelanocortin neurons. Am JPhysiol Regul Integr Comp Physiol. 2013: 305:R359-R368. PMCID:PMC3833394
    23. Dubinion JH, do Carmo JM, Adi A, Hamza S, da Silva AA, Hall JE. Role of proopiomelanocortin neuron Stat3 in regulating arterial pressure and mediating the chronic effects of leptin. Hypertension. 2013; 61:1066-1074. PMCID: PMC3678380
    24. Eirin A, Zhu XY, Li Z, Ebrahimi B, Zhang X, Tang H, Korsmo M, Chade AR, Grande JP, Lerman A, Textor S, Lerman, LO. Endothelial outgrowth cells shift macrophage phenotype and improve kidney viability in swine renal artery stenosis. Arterioscler Thromb Vasc Biol. 2013; 33:1006-1013. PMCIDPMC3644980
    25. Flynn E, Lee J, Hutchens ZM, Chade AR, Maric-Bilkan C. C-peptide preserves the renal microvasculature architecture in the streptozotocin-induced diabetic rat. J Diabetes Complications. 2013; 27:538-547. PMCID: PMC3818424
    26. Franceschini N, Fox E, Zhang Z, Edwards TL, Nalls MA, Sung YJ,Tayo BO, Sun YV, Gottesman O, Adeyemo A, Johnson AD, Young JH, RiceK, Duan Q, Chen F, Li Y, Tang H, Fornage M, Keene KL, Andrews JS,Smith JA, Faul JD, Guangfa Z, Guo W, Liu Y, Murray SS, Musani SK,Srinivasan S, Velez Edwards DR, Wang H, Becker LC, Bovet P, BochudM, Broeckel U, Burnier M, Carty C, Chasman DI, Ehret G, Chen WM,Chen G, Chen W, Ding J, Dreisbach AW, Evans MK, Guo X, Garcia ME,Jensen R, Keller MF, Lettre G, Lotay V, Martin LW, Moore JH,Morrison AC, Mosley TH, Ogunniyi A, Palmas W, Papanicolaou G,Penman A, Polak JF, Ridker PM, Salako B, Singleton AB, Shriner D,Taylor KD, Vasan R, Wiggins K, Williams SM, Yanek LR, Zhao W,Zonderman AB, Becker DM, Berenson G, Boerwinkle E, Bottinger E,Cushman M, Eaton C, Nyberg F, Heiss G, Hirschhron JN, Howard VJ,Karczewsk KJ, Lanktree MB, Liu K, Liu Y, Loos R, Margolis K, SnyderM; Asian Genetic Epidemiology Network Consortium, Psaty BM, Schork NJ, Weir DR, Rotimi CN, Sale MM, Harris T, Kardia SL, Hunt SC,Arnett D, Redline S, Cooper RS, Risch NJ, Rao DC, Rotter JI,Chakravarti A, Reiner AP, Levy D, Keating BJ, Zhu X. Genome-wide association analysis of blood-pressure traits in African-ancestry individuals reveals common associated genes in African and non-African populations.  Am J Hum Genet. 2013;93:545-554. PMCID: PMC3769920
    27. George, EM, Palei AC, Dent EA, Granger JP.  Sildenafil attenuates placental ischemia induced hypertension. Am JPhysiol Regul Comp Physiol. 2013; 305:R397R403. PMCID:PMC3833396
    28. George EM, Stec DE, and Granger JP. Heme oxygenase inhibition increases blood pressure in pregnant rats.  Am J Hypertens.  2013: 26:924-930. PMCID: PMC3731822
    29. Halade GV, Ma Y, Ramirez TA, Zhang J, Dai Q, Hensler JG, LopezEF, Ghasemi O, Jin YF, Lindsey ML. Reduced BDNF attenuates inflammation and angiogenesis to improve survival and cardiac function following myocardial infarction in mice. Am J Physiol Heart Circ Physiol. 2013;305:H1830-H1842.  PMCID: PMC3882541
    30. Hall JE, do Carmo JM, da Silva AA, Wang Z, Hall ME. Role of the kidney in hypertension.  In: Hypertension.  Eds. EL Schiffrin and RM Touyz.  Futura Science Group, 2013.pp 2-19.  Doi:10.2217/EBO.12.475
    31. Heaberlin JR, Ma Y, Zhang J, Ahuja SS, Lindsey ML, Halade GV. Obese and diabetic KKAy mice show increased mortality but improved cardiac function following myocardial infarction.  Cardiovasc Pathol. 2013; 22:481-487. PMCID: PMC3965668
    32. Iliescu R, Tudorancea I, Irwin ED, Lohmeier TE. Chronic baroreflex activation restores spontaneous baroreflex control and variability of heart rate in obesity-induced hypertension. Am J Physiol Heart Circ Physiol. 2013; 305:H1080-H1088. PMCID: PMC3798752
    33. Intapad S, Alexander BT. Future cardiovascular risk:Interpreting the importance of increased blood pressure during pregnancy. Circulation. 2013; 127:668-699.
    34. Intapad S, Tull FL, Brown AD, Dasinger JH, Ojeda NB, Fahling JM, Alexander BT. Renal denervation abolishes the age-dependent increase in blood pressure in female intrauterine growth-restricted rats at 12 months of age. Hypertension.  2013;61:828-834. PMCID: PMC3626267
    35. Intapad S, Alexander BT. Pregnancy complications and later development of hypertension. Curr Cardiovasc Risk Rep.  2013; 7:183-189. PMCID: PMC3728277
    36. Kojima N, Slaughter TN, Paige A, Kato S, Roman RJ, Williams JM. Comparison of the development diabetic induced renal disease in strains of Goto-Kakizaki rats. J Diabetes Metab. 2013;Suppl 9. pii:S9:005. PMCID: PMC3853344
    37. Kojima N, Williams JM, Takahashi T, Miyata N, Roman RJ. Effects of a new SGLT2 inhibitor, luseogliflozin, on diabetic nephropathy in T2DN rats. J Pharmacol Exp Ther. 2013; 345:464-472. PMCID: PMC3657104
    38. Li W, Prakash R, Chawla D, Du W, Didion SP, Filosa JA, Zhang Q,Brann DW,  Lima VV, Tostes RC, Ergul A. Early effects of high fat diet on neurovascular function and focal ischemic brain injury. Am J Physiol. Regul Integr Comp Physiol. 2013;304:R1001-R1008. PMCID: PMC3680754
    39. Lohmeier TE, Iliescu R. The sympathetic nervous system in obesity hypertension. Curr Hypertens Rep. 2013:15:409-416.  PMCID: PMC3714347
    40. Lohmeier TE, Iliescu R. Chronic activation of the baroreflex and the promise for hypertension therapy. Handbook of Clinical Neurology. 2013; 117:395-406.
    41. Lu S, Xiang L, Clemmer J, Gowdey A, Mittwede P, Hester R.  Impaired vascular KATP function attenuates exercise capacity in obese Zucker rats. Microcirculation. 2013; 20:662-669. PMCID: PMC3778059
    42. Lynch CM, Kinzenbaw D, Chen X, Zhan S, Mezzetti EM, Filosa J, Ergul A, Faraci FM,  Didion SP. Nox 2-derived superoxide contributes to cerebral vascular dysfunction in diet-induced obesity. Stroke. 2013; 44:3195-3201.
    43. Mittwede PN, Xiang L, Lu S, Clemmer JS, Hester RL.  A novel experimental model of orthopedic trauma with acute kidney injury in obese Zucker rats.  Physiol Rep.2013;  Oct;1(5):e00097. doi: 10.1002/phy2.97. PMCID:PMC3841033
    44. Palei AC, Spradley FT, Warrington JP, George EM, Granger JP.  Pathophysiology of hypertension in pre-eclampsia: a lesson in integrative physiology.  Acta Physiol(Oxf). 2013; 208: 227-233. PMCID: PMC3687012
    45. Sasser JM. The emerging role of relaxin as a novel therapeutic pathway in the treatment of chronic kidney disease. Am J Physiol Regul Integr Comp Physiol. 2013;305:R559-R565. PMCID: PMC3763042
    46. Slaughter TN, Paige A, Spires D, Kojima N, Kyle PB, Garrett MR, Roman RJ, Williams JM. Characterization of the development of renal injury in Type-1 diabetic Dahl salt-sensitive rats. Am J Physiol Regul Integr Comp Physiol. 2013; 305:R727-R734. PMCID:PMC3798803
    47. Warrington JP, Palei AC, Spradley FT, George EM, Granger JP.  Recent advances in the understanding of the pathophysiology of preeclampsia. Hypertension. 2013;62:666-673. PMCID: PMC3856636.
    48. Xiang L, Clemmer JS, Lu S, Mittwede PN. Impaired blood pressure compensation following hemorrhage in conscious obese Zucker rats. Life Sci. 2013; 93:214-219.
    49. Ying Z, do Carmo JM, Xiang L, da Silva AA, Chen M, Ryan MJ, Ostrowski M, Rajagopalan S, Hall JE. Inhibitor kB kinase 2 is amyosin light chain kinase in vascular smooth muscle. Circ Res. 2013; 113:562-570. PMCID: PMC3970202
    50. Zouein FA, de Castro Brás LE, da Costa DV, Lindsey ML, Kurdi M, Booz GW. Heart failure with preserved ejection fraction: emerging drug strategies. J Cardiovasc Pharmacol. 2013; 62:13-21. PMCID:PMC3724214
    51. Zouein FA, Zgheib C, Hamza S, Fuseler JW, Hall JE, Solijancic A, Ruiz AL, Kurdi M, Booz GW. Role of STAT3 in angiotensin II-induced hypertension and cardiac remodeling revealed by mice lacking STAT3 serine 727 phosphorylation. Hypertension Res. 2013; 36: 496-503. PMID: 23364341. 
    52. Bressler J, Fornage M, Demerath EW, Knopman DS, Monda KL, North KE, Penman A, Mosley TH, Boerwinkle E.  Fat mass and obesity gene and cognitive decline:  the Atherosclerosis Risk in Communities Study.  Neurology.  2013;80:92-99.  PMCID:PMC3589198
    53. Liu J, Musani SK, Bidulescu A, Car JJ, Wilson JG, Taylor HA, Fox CS.  Fatty liver, abdominal adipose tissue and atherosclerotic calcification in African Americans:  the Jackson Heart Study.  Atherosclerosis.  2012;224:521525.  PMCID:PMC3459068
    54. Bassi M, do Carmo JM, Hall JE, da Silva AA.  Chronic effects of centrally administered adiponectin on appetite, metabolism and blood pressure regulation in normotensive and hypertensive rats.  Peptides.  2012;37:1-5.  PMCID:PMC3427463  
    55. Jones E, Eyler AA, Nguyen L, Kong J, Brownson RC, Bailey JH.  It's all in the lens:  differences in views on obesity prevention between advocates and policy makers.  Chil Obes.  2012;8:243-250.  PMID:  22799551
    56. Fülöp T, Hickson DA, Wyatt SB, Bhagat R, Rack M, Gowdy O Jr, Flessner MF, Taylor HA.  Sleep-disordered breathing symptoms among African-Americans in the Jackson Heart Study.  Sleep Med.  2012;13:1039-1049.  PMCID:  PMC3427405