Sharon A. Lobert, PhD, RN
 | Professor of Nursing and Biochemistry Associate Dean for Research, Practice and Evaluation
View CV Contact - Phone: (601) 984-6242
- Fax: (601) 984-6191
- E-mail: slobert@umc.edu
- Office: Jackson campus
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Biography
Dr. Sharon Lobert is associate dean for research, practice and evaluation in the School of Nursing and a professor in the Schools of Nursing and Medicine (Department of Biochemistry). She joined the University of Mississippi Medical Center in August 2000. She is currently responsible for oversight of the School of Nursing's research, practice and evaluation activities.
She has an active basic science research program related to oncology and oncology nursing, as well as an ongoing clinical study for validation of predictive biomarkers for head and neck cancer. She uses cell culture models to study drug resistant mechanisms in the laboratory. She has numerous national and international publications and presentations in her research area and a consistent history of extramural private and federal funding for her research program.
Research overview
Dr. Lobert's long-range goal is to understand why tumors are resistant to antimitotic chemotherapy agents.
Antimitotic agents have been important in cancer chemotherapy for more than 35 years. Often tumors are resistant to antimitotic agents either initially or after repeated drug cycles. These drugs interact with tubulin, the major protein of mitotic spindles. Mitotic microtubules are dynamic, undergoing assembly and disassembly while aligning chromosomes at the metaphase plate. Antimitotics halt cell division at metaphase by altering microtubule dynamics.
She has three ongoing projects investigating acute lymphoblastic leukemia, breast cancer and non-small cell lung-cancer responses to antimitotic drugs, such as paclitaxel and vincristine. These projects are carried out through collaborations with students and colleagues at UMMC, as well as other universities. The School of Nursing basic science laboratories are equipped for state-of-the-art cell culture, molecular biology, fluorescence microscopy and protein chemistry studies.