Faculty

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  • Junming Wang, PhD

    Wang, Jumming-web.jpgAssociate Professor, Research
    Adjunct Faculty, Psychiatry and Human Behavior; Memory Impairment and Neurogenerative Dementia (MIND Center); Pharmacology and Toxicology
    Phone: (601) 984-1570
    E-mail: jwang@umc.edu

    Education

    • Master of Medicine - Xian Medical University, China
    • PhD - Department of Medicine, University of Antwerp, Belgium
    • Postdoctoral training - University of Ottawa, Canada
    • Research assistant professor - University of Southern California, Los Angeles, CA

    Research interests

    The focus of Dr. Wang 's research are: 1) The development of neurogenic and neuroprotective drugs to treat neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease; 2) The molecular, and neuronal mechanisms of Neuropathology progression of Parkinson's and Alzheimer's diseases; and 3) The translation of animal experimental results to human clinical applications.

    Professional activities

    • Memberships
      • New York Academy of Sciences
      • The Society for Neuroscience
      • International Society to Advance Alzheimer Research and Treatment

    Selected Publications

    • Adeosun S, Hou X, Jiao Y, Zheng B, Henry S, Hill R, Pani A, Kyle P, Farley J, Stockmeier C, Paul I, Bigler S, Brinton RD, Smeyne R, Wang JM. The Impact of a Neurosteroid Agent, Allopregnanolone, in a rodent model of Parkinson’s disease. Plos One, 2012, in revising
    • Wang JM, Hou X, Adeosun S, Hill R. Henry S, Paul I, Irwin RW, Ou, X, Bigler S, Stockmeier C, Brinton RD and Gomez-Sanchez E. A Dominant Negative ERβ Splice Variant Determines the Effectiveness of Early or Late Estrogen Therapy after Ovariectomy in Rats. Plos One, 2012, 7(3):e33493, PMID: 22428062
    • Sun C, Ou X, Farley JM, Stockmeier C, Bigler S, Brinton RD, Wang JM. Allopregnanolone Increases the Number of Dopaminergic Neurons in Substantia Nigra of A Triple Transgenic Mouse Model of Alzheimer’s Disease. Current Alzheimer Research, 2012, 9(4):473-480. PMID: 22272610
    • Wang JM et al. Allopregnanolone Reverses Neurogenic and Learning and Memory Deficits in Mouse Model of Alzheimer’s Disease. Proc Natl Acad Sci U S A, 2010, 107(14):6498-6503. PMID: 20231471
    • Wang JM and Brinton RD. Allopregnanolone-Induced Rise in Intracellular Calcium in Embryonic Hippocampal Neurons Parallels Their Proliferative Potential. BMC Neurosci. 2008, 9 (Suppl 2):S11. PMID: 19090984
    • Wang JM et al. Estradiol-17beta-induced human neural progenitor cell proliferation is mediated by an estrogen receptor beta-phosphorylated extracellularly regulated kinase pathway. Endocrinology. 2008 149(1):208-218. PMID: 17962344
    • Wang JM et al. Regenerative potential of allopregnanolone. Brain Res. Rev. 2008, 57:398-409. PMID: 17931704
    • Wang JM, Irwin RW, Brinton RD. Activation of Estrogen Receptor α Increases and Estrogen Receptor β Decreases Apolipoprotein E Expression in Hippocampus In Vitro and In Vivo. Proc Natl Acad Sci U S A. 2006, 103:16983-16988. PMID: 17077142
    • Wang JM et al. The neurosteroid allopregnanolone promotes proliferation of neural progenitor cells and regulates gene expression of cell cycle proteins. Journal of Neuroscience 2005, 25:4706-4718. PMID: 15888646
    • Wang JM et.al. Effects of High salt intake on brain angiotensin II receptor density in Dahl rats. American Journal of Physiology 2003, 285:H1949-H1955. PMID: 12842816
    • Wang JM et al. Presence of a cellular renin angiotensin system in chromaffin cells of bovine adrenal medulla. American Journal of Physiology 2002, 283:H1811-H1818. PMID: 12384458
    • Wang JM et. al. Developmental effects of ectopic expression of the glucocorticoid receptor DNA binding domain are alleviated by an amino acid substitution that interferes with homeodomain binding. Molecular and Cellular Biology 1999, 19:7106-7122. PMID: 10490647
    • Wang JM et al. Expression of angiotensinogen mRNA and localization of angiotensin II and renin in peripheral adrenergic neurons in primary culture. Biochemical and Biophysical Research Communications 1996, 229:876-881. PMID: 8954987
    • Wang JM et al. Phenotype plasticity and immunocytochemical evidence for CHAT and DßH co-localization in fetal pig superior cervical ganglia cells. Brain Research Developmental Brain Research 1995, 90:17-23. PMID: 8719326
    • Wang JM et. al. Conversion of angiotensin II into active fragments by an early endosomal pathway in bovine adrenal medullary cells in primary culture. Endocrinology 1995, 136:5274-5282. PMID: 7588271