Endocrinology Fellowship

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  • Selected Publications

    • Koch CA, Pacak K, Chrousos GP. The molecular pathogenesis of hereditary and sporadic adrenocortical and adrenomedullary tumors. J Clin Endocrinol Metab 2002;87:5367-5384
    • Huang SC, Torres-Cruz J, Pack SD, Koch CA, Vortmeyer AO, Mannan P, Lubensky IA, Gagel RF, Zhuang Z. Amplification and overexpression of mutant RET in MEN2-associated medullary thyroid carcinoma. J Clin Endocrinol Metab 2003;88:459-463
    • Miehle K, Tannapfel A, Lamesch P, Borte G, Schenker E, Kluge R, Ott RA, Wiechmann V, Koch M, Paschke R, Koch CA. Pancreatic neuroendocrine tumor with ectopic ACTH-production upon second recurrence. J Clin Endocrinol Metab 2004;89:3731-3736
    • Miehle K, Kratzsch J, Lenders JW, Kluge R, Paschke R, Koch CA. Adrenal incidentaloma diagnosed as pheochromocytoma by plasma chromogranin A and plasma metanephrines. J Endocrinol Invest. 2005 Dec;28(11):1040-2.
    • Wiesner TD, Trantakis C, Meixensberger J, Koch CA, Zimmer C, Paschke R. Structure of an interdisciplinary pituitary outpatient care unit at the University Hospital of Leipzig and results for treatment of prolactin and growth hormone secreting pituitary tumors. Med Klin (Munich). 2005 Apr 15;100(4):173-9.
    • Koch CA, Brouwers FM, Vortmeyer AO, Tannapfel A, Libutti SK, Zhuang Z, Pacak K, Neumann HPH, Paschke R. Somatic VHL gene alterations in MEN2-associated medullary thyroid carcinoma. BMC Cancer 2006, May 17, 6:131
    • Anlauf M, Schlenger R, Perren A, Bauersfeld J, Koch CA, Dralle H, Raffel A, Knoefel WT, Weihe E, Ruszniewski P, Couvelard A, Komminoth P, Heitz PU, Kloppel G. Microadenomatosis of the endocrine pancreas in patients with and without the multiple endocrine neoplasia type 1 syndrome. Am J Surg Pathol. 2006 May;30(5):560-74.
    • Fasshauer M, Lincke T, Witzigmann H, Kluge R, Tannapfel A, Moche M, Buchfelder M, Petersenn S, Kratzsch J, Paschke R, Koch CA. Ectopic Cushing' syndrome caused by a neuroendocrine carcinoma of the mesentery. BMC Cancer. 2006 Apr 27;6:108.
    • Georgitsi M, Raitila A, Karhu A, van der Luijt RB, Aalfs CM, Sane T, Vierimaa O, Makinen MJ, Tuppurainen K, Paschke R, Gimm O, Koch CA, Gundogdu S, Lucassen A, Tischkowitz M, Izatt L, Aylwin S, Bano G, Hodgson S, De Menis E, Launonen V, Vahteristo P, Aaltonen LA. Germline CDKN1B/p27Kip1 Mutation in Multiple Endocrine Neoplasia. J Clin Endocrinol Metab. 2007;92(8):3321-5
    • Kazi M, Geraci SA, Koch CA. Considerations in diagnosing and treating testosterone deficiency in elderly men. Am J Med. 2007:120(10)
    • Gomez-Sanchez CE, de Rodriguez AF, Romero DG, Estess J, Warden MP, Gomez-Sanchez MT, Gomez-Sanchez EP,. Development of a panel of monoclonal antibodies against the mineralocorticoid receptor. Endocrinology. 2006 Mar;147(3):1343-8.
    • Gomez-Sanchez, E.P., Ahmad, N., Romero, D.G., and Gomez-Sanchez, C.E. 2005. Is aldosterone synthesized within the rat brain? Am J Physiol Endocrinol Metab 288:E342-346.
    • Romero DG, Vergara GR, Zhu Z, Covington GS, Plonczynski MW, Yanes LL, Gomez-Sanchez EP, Gomez-Sanchez CE. Interleukin-8 synthesis, regulation, and steroidogenic role in H295R human adrenocortical cells. Endocrinology. 2006 Feb;147(2):891-8.
    • Morita, H., Isomura, Y., Mune, T., Daido, H., Takami, R., Yamakita, N., Ishizuka, T., Takeda, N., Yasuda, K., and Gomez-Sanchez, C.E. 2004. Plasma cortisol and cortisone concentrations in normal subjects and patients with adrenocortical disorders. Metabolism 53:89-94.
    • Mulatero, P., Stowasser, M., Loh, K.C., Fardella, C.E., Gordon, R.D., Mosso, L., Gomez-Sanchez, C.E. , Veglio, F., and Young, W.F., Jr. 2004. Increased diagnosis of primary aldosteronism, including surgically correctable forms, in centers from five continents. J Clin Endocrinol Metab 89:1045-1050.
    • Ahmad, N., Romero, D.G., Gomez-Sanchez, E.P., and Gomez-Sanchez, C.E. 2004. Do human vascular endothelial cells produce aldosterone? Endocrinology 145:3626-3629.
    • Khan, U., and Gomez-Sanchez, C.E. 2004. Primary aldosteronism: evolving concepts in diagnosis and treatment. Curr Opin Endocrinol Diabetes 11:153-157.
    • Romero, D.G., Plonczynski, M., Vergara, G.R., Gomez-Sanchez, E.P., and Gomez-Sanchez, C.E. 2004. Angiotensin II early regulated genes in H295R human adrenocortical cells. Physiol Genomics 19:106-116.
    • Gomez-Sanchez, E.P., Ahmad, N., Romero, D.G., and Gomez-Sanchez, C.E. 2004. Origin of aldosterone in the rat heart. Endocrinology 145:4796-4802.
    • Carvajal, C.A., Gonzalez, A.A., Romero, D.G., Gonzalez, A., Mosso, L.M., Lagos, E.T., Hevia Md Mdel, P., Rosati, M.P., Perez-Acle, T.O., Gomez-Sanchez, C.E., et al. 2003. Two homozygous mutations in the 11beta-hydroxysteroid dehydrogenase type 2 gene in a case of apparent mineralocorticoid excess. J Clin Endocrinol Metab 88:2501-2507.
    • Gomez-Sanchez, E.P., and Gomez-Sanchez, C.E. 2003. Is aldosterone synthesized in the CNS regulated and functional? Trends Endocrinol Metab 14:444-446.
    • Romero DG, Yanes LL, de Rodriguez AF, Plonczynski MW, Welsh BL, Reckelhoff JF, Gomez-Sanchez EP, Gomez-Sanchez CE. Disabled-2 is expressed in adrenal zona glomerulosa and is involved in aldosterone secretion. Endocrinology. 2007 Jun: 148(6):2644-52.
    • Zubkova, I., and Subauste, J.S. (2003) Sequences required for the transition from monomeric to homodimeric forms of thyroid hormone receptor alpha and v-erbA. Mol. Cell. Endocrinol. 199, 61-72.
    • Bratton, M.R., Gomez-Sanchez, E.P., Gomez-Sanchez, C.E., and Subauste, J.S. (2004). The myosin binding protein is a novel mineralocorticoid receptor binding partner. Mol. Cell. Endocrinol. 217, 243-249.
    • Zubkova, I., and Subauste, J.S. (2004) V-erbA homodimers mediate the potent dominant negative activity of v-erbA on everted repeats. Mol. Biol. Reports. 31, 131-137.
    • Lu, D., Ventura-Holman, T., Li, j., Mcmurray, R.W., Subauste, J.S. , and Maher, J.F. (2005) Abnormal glucose homeostasis and pancreatic islet function in mice with inactivation of the Fem1b gene. Mol. Cell. Biol. 15, 6570-6577.
    • Ventura-Holman, T., Hahn, H., Subauste, J.S. , and Maher, J.F. (2005) The Fem1a gene is down-regulated in rhabdomyosarcoma. Tumor Biol. 26, 294-299.
    • Maher, J.F., Hines, R.S., Futterweit, W., Crawford, S., Lu, D., Shen, P., Oefner, P., Kazi, M., Wilson, J.G., Subauste, J.S. , and Cowan, B.D. (2005) Fem1a is a candidate gene for polycystic ovary syndrome. Gynecol. Endocrinol. 21, 330-335.
    • Ventura-Holman T, Mamoon A, Maher JF, Subauste JS. Thyroid hormone responsive genes in the murine hepatocyte cell line MAL. Gene 2007;396(2):332-7  
    • Jones D, May K, Geraci S Subclinical Thyroid Disease. The American Journal of Medicine. 2010; 123:502-504.
    • Gomez-Sanchez EP , Gomez-Sanchez CM, Plonczynski M, Gomez-Sanchez CE Aldosterone synthesis in the brain contributes to Dahl salt-sensitive rat hypertension. Exp Physiol. 2010; 95:120-130.
    • Gomez-Sanchez CE, Gomez-Sanchez EP Aldosterone-producing adenomas: mining for genes. Hypertension. 2010; 55:1306-1307.
    • Romero DG, Gomez-Sanchez EP, Gomez-Sanchez CE Angiotensin II-regulated transcription regulatory genes in adrenal steroidogenesis. Physiol Genomics. 2010; 42A: 259-266.
    • Gomez-Sanchez EP The mammalian mineralocorticoid receptor: tying down a promiscuous receptor. Exp Physiol. 2010; 95:13-18.
    • Ackermann D, Gresko N, Carrel M, Loffing-Cueni D, Habermehl D, Gomez-Sanchez CE , Rossier BC, Loffing J In vivo nuclear translocation of mineralocorticoid and glucocorticoid receptors in rat kidney: differential effect of corticosteroids along the distal tubule. Am J Physiol Renal Physiol. 2010; 299:F1473-1485.
    • Faresse N, Ruffieux-Daidie D, Salamin M, Gomez-Sanchez CE , Staub O Mineralocorticoid receptor degradation is promoted by Hsp90 inhibition and the ubiquitin-protein ligase CHIP. Am J Physiol Renal Physiol. 2010; 299:F1462-1472.
    • Gomez-Sanchez CE , Rossi GP, Fallo F, Mannelli M Progress in Primary Aldosteronism: Present Challenges and Perspectives. Horm Metab Res. 2010; 42:374-381.
    • Quinta HR, Maschi D, Gomez-Sanchez CE , Piwien-Pilipuk G, Galigniana MD Subcellular rearrangement of hsp90-binding immunophilins accompanies neuronal differentiation and neurite outgrowth. J Neurochem. 2010.
    • Gagligniana MD, Erlejman AG, Monte M, Gomez-Sanchez C , Piwien-Pilipuk G The hsp90-FKBP52 Complex Links the Mineralocorticoid Receptor to Motor Proteins and Persists Bound to the Receptor in Early Nuclear Events. Mol Cell Biol. 2010; 30:1285-1298.
    • Spyroglou A, Wagner S, Gomez-Sanchez CE , Rathkolb B, Wolf E, Manolopoulou J, Reincke M, Bidlingmaier M, Hrabe de Angelis M, Beuschlein F Utilization of a mutagenesis screen to generate mouse models of hyperaldosteronism. Endocrinology. 2010; 152:326-331.
    • Majumdar S, Friedrich CA, Koch CA , Megason GC, Fratkin JD, Moll GW. Compound heterozygous mutation with a novel splice donor region DNA sequence variant in the succinate dehydrogenase subunit B gene in a boy with malignant paraganglioma. Pediatr Blood Cancer. 2010;54(3):473-5 (IF 2.4).
    • Singer J, Werner F, Koch CA , Bartels M, Aigner T, Lincke T, Fasshauer M, Paschke R. Ectopic Cushing's syndrome caused by a well differentiated ACTH-secreting neuroendocrine carcinoma of the ileum. Exp Clin Endocrinol & Diab. 2010;118(8):524-9.
    • Mohammed R, Norton J, Geraci SA, Newman BD, Koch CA. Prolonged QTc interval due to escitalopram overdose. J Miss State Med Assoc. 2010;12:350-353.
    • Spyroglou A, Wagner S, Gomez-Sanchez CE , Rathkolb B, Wolf E, Manolopoulou J, Reincke M, Bidlingmaier M, Hrabe de Angelis M, Beuschlein F Utilization of a mutagenesis screen to generate mouse models of hyperaldosteronism. Endocrinology. 2011; Jan 152(1):326-31. Epub 2010 Nov.
    • Xue B, Beltz TG, Yu Y, Guo F, Gomez-Sanchez CE , Hay M, Johnson AK Central interactions of aldosterone and angiotensin II in aldosterone- and angiotension II-induced hypertension. Am J Physiol Heart Circ Physiol. 2011; Feb 300(2):H555-564. Epub 2010 Nov.
    • East H, Riche D, Sheehan N, Koch CA Severe Hypocalcemia Caused by Clostridium Difficile Colitis Requiring 22 GMs of Magnesium Sulfate Infusion. Journal of Investigative Medicine. 2011; 59:410.  
    • Koch CA Primary hypothyroidism associated with acute mania: case series and literature review.. Exp Clin Endocrinol & Diab. 2011 May; 119(8):513-517 (IF 1.7).
    • Xing Y, Edwards MA, Ahlem C, Kennedy M, Cohen A, Gomez-Sanchez CE , Rainey WE The effects of ACTH on steroid metabolomic profiles in human adrenal cells.. J Endocrinol. 2011; Jun 209(3):327-335. Epub 2011 Mar.
    • Taves MD,Gomez-Sanchez CE , Soma KK Extra-adrenal glucocorticoids and mineralocorticoids: evidence for local synthesis, regulation, and function. Am J Physiol Endocrinol Metab. 2011; Jul 301(1):E11-24. Epub 2011 May.
    • Nakamura Y, Satoh F, Morimoto R, Kudo M, Takase K, Gomez-Sanchez CE , Honma S, Okuyama M, Yamashita K, Rainey WE, Sasano H, Ito S 18-oxocortisol measurement in adrenal vein sampling as a biomarker for subclassifying primary aldosteronism. J Clin Endocrinol Metab. 2011; Aug 96(8):E1272-8. Epub 2011 May 18.
    • Zhu X, Manning RD Jr, Lu D, Gomez-Sanchez CE , Fu Y, Juncos LA, Liu R Aldosterone stimulates superoxide production in macula densa cells. Am J Physiol Renal Physiol. 2011; Sep 301(3):F529-35. Epub 2011 Jan.
    • Maniero C, Fassina A, Guzzardo V, Lenzini L, Amadori G, Pelizzo MR, Gomez-Sanchez CE , Rossi GP Primary hyperparathyroidism with concurrent primary aldosteronism. Hypertension. 2011; Sep 58(3):341-6. Epub 2011 Aug 8.
    • Chaithongdi N, Subauste J, Koch CA , Geraci S Diagnosis and management of hyperglycemic emergencies. Hormones. 2011; 10.
    • Verhovez A, Williams TA, Morello F, Monticone S, Brizzi MF, Dentelli P, Fallo F, Fabris B, Amenta F, Gomez-Sanchez CE , Veglio F, Mulatero P Aldosterone does not modify gene expression in human endothelial cells. Horn Metab Res. 2011; Nov 8.
    • Gomez-Sanchez EP Mineralocorticoid receptors in the brain and cardiovascular regulation: minority rule?. Trends Endocrinol Metab. 2011.
    • Zhu X, Manning RD, Lu D, Gomez-Sanchez CE , Fu Y, Juncos LA, Liu R Aldosterone stimulates superoxide production in macula densa cells. Am J Physiol Renal Physiol. 2011; 201:F529-535.
    • Singer J, Koch CA , Kassahun W, Lamesch P, Eisenhofer G, Kluge R, Lincke T, Seiwerts M, Borte G, Schierle K, Paschke R Pitfalls of diagnosis in a patient with a large recurrent pheochromocytoma. Nat Rev Endocrinol. 2011; 7(12):749-55 (IF 9.2).
    • Ventura-Holman T, Mamoon A, Subauste MC, Subauste J The effect of oncoprotein v-erbA on T3-regulated genes in hepatocytes and their potential role in hepatocellular carcinoma. Mol Biol Rep. 2011; 38:1137-1144.
    • Gomez-Sanchez CE , Warden M, Gomez-Sanchez MT, Hou X, Gomez-Sanchez EP Diverse immunostaining patterns of mineralocorticoid receptor monoclonal antibodies. Steroids. 2011; Dec 20;76(14):1541-4. Epub 2011 Sep.
    • Mulatero P, Morra di Cella S, Monticone S, Schiavone D, Manzo M, Mengozzi G, Rabia F, Terzolo M, Gomez-Sanchez EP, Gomez-Sanchez CE , Veglio F 18-Hydroxycorticosterone, 18-Hydroxycortisol, and 18-Oxocortisol in the diagnosis of primary aldosteronism and its subtypes. J Clin Endocrinol Metab. 2012 Jan 11.
    • Gomez-Sanchez CE, Gomez-Sanchez EP Mutations of the potassium channel KCNJ5 causing aldosterone-producing adenomas: one or two hits?. Hypertension. 2012; Feb 59(2):196-7. Epub 2011 Dec.
    • Oki K, Gomez-Sanchez EP, Gomez-Sanchez CE Role of mineralocorticoid action in the brain in salt-sensitive hypertension. Clin Exp Pharmacol Physiol. 2012; Jan39(1):90-5.
    • Oki K, Plonczynski MW, Luis Lam M, Gomez-Sanchez EP, Gomez-Sanchez CE Potassium channel mutant KCNJ5 T158A expression in HAC-15 cells increases aldosterone synthesis. Endocrinology. 2012 Feb 7.
    • Fu Y, Hall JE, Lu D, Lin L, Manning RD Jr, Cheng L, Gomez-Sanchez CE , Juncos LA, Liu R Aldosterone Blunts Tubuloglomerular Feedback by Activating Macula Densa Mineralocorticoid Receptors. Hypertension. 2012; Feb 6.
    • Gomez-Sanchez CE, Gomez-Sanchez EP Mutations of the potassium channel KCNJ5 causing aldosterone-producing adenomas: one or two hits?. Hypertension. 2012; Feb 59(2):196-7. Epub 2011 Dec 27.
    • Oki K, Plonczynski MW, Luis Lam M, Gomez-Sanchez EP, Gomez-Sanchez CE Potassium Channel Mutant KCNJ5 T158A Expression in HAC-15 Cells Increases Aldosterone Synthesis. Endocrinology. 2012; Feb 7.
    • Gomez-Sanchez EP, Gomez-Sanchez CE Central regulation of blood pressure by the mineralocorticoid receptor. Mol Cell Endocrinol. 2012; Mar 24;350(2):289-98. Epub 2011 Jun.
    • French SE, Subauste JS , Geraci SA Calcium abnormalities in hospitalized patients. Southern Medical Journal. 2012; 105:231-237.
    • Fleseriu M, Biller BMK, Findling JW, Molitch ME, Schteingart DE, Gross C, on behalf of the SEISMIC study investigators (Koch CA) Mifepristone, a glucocorticoid receptor antagonist, produces clinical and metabolic benefits in patients with Cushing's syndrome. J Clin Endocrinol Metab. 2012 Jun; 97(6):2039-49 (IF 6.4).
    • Hawkins U, Gomez-Sanchez EP , Gomez-Sanchez CM, Gomez-Sanchez CE The Ubiquitous Mineralocorticoid Receptor: Clinical Implications. Curr Hypertens Rep. 2012 July.
    • Koch CA , Kemp S Androgen Insensitivity Syndrome. Medscape Reference. 2012.