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General: Cerebrovascular, cardiovascular, and reproductive physiology.
Specific: Cerebrovascular abnormalities in pregnancy and preeclampsia, cerebral edema, blood-brain barrier permeability, cerebral blood flow autoregulation, cerebrovascular myogenic reactivity.
Research methods: Surgical techniques such as: Rat and mouse model of placental ischemia (reduced uterine perfusion pressure), chronic infusions via implantation of mini-osmotic pumps. Molecular techniques such as: Western blot, ELISA, histology, vessel transfections, etc… Acute measurement of arterial blood pressure via catheter, Ex-vivo measurement of cerebrovascular function, cerebral blood flow autoregulation.
Current Projects: Mechanisms for placental ischemia mediated cerebrovascular abnormalities
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