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  • Research Summary of Terry Dwyer, MD, PhD

    Research summary

    I. Airways require a thin coating of fluid to maintain healthy; too much, or fluid that contains too much mucus restricts airflow, or allows for the colonization by pathogenic bacteria. Many inflammatory processes combine to both increase the quantity of fluid, and alter its physical character. We are currently investigating the cellular mechanisms by which inflammation alters airway fluid as well as non-invasive methods of monitoring airway fluid composition.

    II. Blood pressure increases (on average) with adiposity; in Western societies, this means that blood pressure increases with the weight gain that accompanies aging. Renal function is altered in human and animal models of obesity (increased renal blood flow and glomerular filtration), as is renal structure (increased fat in the renal sinus, and increased medullary interstitial volume due to elevated levels of hyaluronic acid). We are studying the mechanisms by which the interstitium is altered, and the functional consequence of those changes.

    Selected articles

    • Dwyer TM. The electrochemical basis of nerve function. Fundamental Neuroscience for Basic and Clinical Applications. D. E. Haines (Ed.). Churchill Livingstone Elsevier. Philadelphia. 2006.
    • Dwyer TM and Schmidt-Nielsen B. The Renal Pelvis: Machinery That Concentrates Urine in the Papilla. News in Physiol. Sci. 18: 1-8, 2003.
    • Knepper MA, Saidel GM, Hascall VC and Dwyer TM. Solute concentration in the renal inner medulla: Interstitial hyaluronan as a mechano-osmotic transducer. Am. J. Physiol. (Renal Physiol.) 284: F1-F15, 2003. short review/book chapter
    • Lohmeier TE, Dwyer TM, Hildebrandt DA, Irwin ED, Rossing MA, Serdar DJ, Kieval RS. Influence of prolonged baroreceptor activation on arterial pressure in angiotensin hypertension. Hypertension. 2005 Nov. 46(5):1194-2000
    • Horvath I, Hunt J, Barnes PJ, Alving K, Antczak A, Baraldi E, Becher G, van Beurden WJ, Corradi M, Dekhuijzen R, Dweik RA, Dwyer T, Effros R, Erzurum S, Gaston B, Gessner C, Greening A, Ho LP, Hohlfeld J, Jobsis Q, Laskowski D, Loukides S, Marlin D, Montuschi P, Olin AC, Redington AE, Reinhold P, van Rensen EL, Rubinstein I, Silkoff P, Toren K, Vass G, Vogelberg C, Wirtz H; ATS/ERS Task Force on Exhaled Breath Condensate Exhaled breath condensate: methodological recommendations and unresolved questions. Eur Respir J. 2005 Sep;26(3):523-48.
    • Website citation: (http://www.apsarchive.org/renalpelvis/index.htm)