Professor and ChairDepartment of Pharmacology & ToxicologyOffice: R418Phone: (601) 984-1602E-mail: RRoman@umc.edu
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My laboratory is interested in the role of the kidney in hypertension and the mechanisms underlying hypertension and diabetic nephropathy. We use an array of techniques including micropuncture, tubular perfusion, intracellular imaging, immunohistochemistry, molecular biology, laser Doppler flowmetry, mass spectroscopy and long term studies in animal models. Currently we are working on projects: 1) to identify genes on chromosome 13 and 5 that protect against the development of hypertension and hypertension induced renal disease in Dahl S rats, 2) to identify a gene on chromosome 1 that regulates renal blood flow and contributes to the development of glomerular disease in Fawn Hooded Hypertensive rats, 3) to identify genes on chromosome 5 and 7 that contribute to the progression of diabetic nephropathy in GK rats, 4) to study the role of cytochrome P450 metabolites of arachidonic acid in the control of tubular sodium transport and the development of hypertension, and 5) to study the mechanism by which hypertension and diabetes increase the renal formation of transforming growth factor beta in the kidney which plays a major role in the development of proteinuria and renal fibrosis.
2500 North State Street
Jackson, MS 39216
General Information: 601-984-1000
Patient Appointments: 888-815-2005