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  • Richard J. Roman, PhD

     Richard J Roman, PhD

    Professor and Chair
    Department of Pharmacology & Toxicology
    Office: R418
    Phone: (601) 984-1602

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    Research interests

    • Cardiovascular physiology
    • Renal physiology
    • Genetics and genomics

    Current research

    My laboratory is interested in the role of the kidney in hypertension and the mechanisms underlying hypertension and diabetic nephropathy. We use an array of techniques including micropuncture, tubular perfusion, intracellular imaging, immunohistochemistry, molecular biology, laser Doppler flowmetry, mass spectroscopy and long term studies in animal models.

    Currently we are working on projects: 1) to identify genes on chromosome 13 and 5 that protect against the development of hypertension and hypertension induced renal disease in Dahl S rats, 2) to identify a gene on chromosome 1 that regulates renal blood flow and contributes to the development of glomerular disease in Fawn Hooded Hypertensive rats, 3) to identify genes on chromosome 5 and 7 that contribute to the progression of diabetic nephropathy in GK rats, 4) to study the role of cytochrome P450 metabolites of arachidonic acid in the control of tubular sodium transport and the development of hypertension, and 5) to study the mechanism by which hypertension and diabetes increase the renal formation of transforming growth factor beta in the kidney which plays a major role in the development of proteinuria and renal fibrosis.

    Selected publications

    • Alexanian, A., Miller, B., Roman, R. J., and Sorokin, A. (2012) 20-HETE-producing Enzymes Are Up-regulated in Human Cancers, Cancer genomics & proteomics 9, 163-169. PubMed article
    • M., Roman, R. J., and Nowicki, S. (2012) Inhibitors of 20-hydroxyeicosatetraenoic acid (20-HETE) formation attenuate the natriuretic effect of dopamine, European journal of pharmacology 686, 97-103. PubMed article 
    • Murphy, S. R., Dahly-Vernon, A. J., Dunn, K. M., Chen, C. C., Ledbetter, S. R., Williams, J. M., and Roman, R. J. (2012) Renoprotective effects of anti-TGF-beta antibody and antihypertensive therapies in Dahl S rats, American Journal of Physiology. Regulatory, integrative and comparative physiology 303, R57-69. PubMed article
    • Williams, J. M., Fan, F., Murphy, S., Schreck, C., Lazar, J., Jacob, H. J., and Roman, R. J. (2012) Role of 20-HETE in the antihypertensive effect of transfer of chromosome 5 from Brown Norway to Dahl salt-sensitive rats, American journal of physiology. Regulatory, integrative and comparative physiology 302, R1209-1218. PubMed article
    • O'Meara, C. C., Lutz, M. M., Sarkis, A. B., Xu, H., Kothinti, R. K., Hoffman, M., Moreno, C., Tabatabai, N. M., Lazar, J., Roman, R. J., and Jacob, H. J. (2012) A 4.1-Mb congenic region of Rf-4 contributes to glomerular permeability, Journal of the American Society of Nephrology : JASN 23, 825-833. PubMed article 
    • Renic, M., Kumar, S. N., Gebremedhin, D., Florence, M. A., Gerges, N. Z., Falck, J. R., Harder, D. R., and Roman, R. J. (2012) Protective effect of 20-HETE inhibition in a model of oxygen-glucose deprivation in hippocampal slice cultures, American journal of physiology. Heart and circulatory physiology 302, H1285-1293. PubMed article
    • Regner, K. R., and Roman, R. J. (2012) Role of medullary blood flow in the pathogenesis of renal ischemia-reperfusion injury, Current opinion in nephrology and hypertension 21, 33-38. PubMed article
    • Guo, A. M., Janic, B., Sheng, J., Falck, J. R., Roman, R. J., Edwards, P. A., Arbab, A. S., and Scicli, A. G. (2011) The cytochrome P450 4A/F-20-hydroxyeicosatetraenoic acid system: a regulator of endothelial precursor cells derived from human umbilical cord blood, The Journal of pharmacology and experimental therapeutics 338, 421-429. PubMed article 
    • Williams, J. M., Zhang, J., North, P., Lacy, S., Yakes, M., Dahly-Vernon, A., and Roman, R. J. (2011) Evaluation of metalloprotease inhibitors on hypertension and diabetic nephropathy, American journal of physiology. Renal Physiology 300, F983-998. PubMed article 
    • Williams, J. M., Burke, M., Lazar, J., Jacob, H. J., and Roman, R. J. (2011) Temporal characterization of the development of renal injury in FHH rats and FHH.1BN congenic strains, American journal of physiology. Renal physiology 300, F330-338. PubMed article