Blood vessels have an intrinsic ability called "myogenic response" that helps to auto regulate blood flow to an organ despite fluctuations in blood pressure. Myogenic response depends on the concerted action of ion-channels and contractile machinery in the vascular smooth muscle cell ultimately leading to contraction of blood vessels. Relevant ion- channels in smooth muscle are being explored, including voltage-dependent calcium channels, inward rectifier potassium channels, calcium-sensitive BK, IK, SK channels, voltage-dependent potassium channels, ATP-sensitive potassium channels, TRPV4 channels, ryanodine receptor channels and IP3R channels. The ultimate goals are to understand the basic mechanisms for ion-channel control of local cerebral blood flow, peripheral resistance and using this information to understand pathologies such as stroke, kidney failure and possible new therapeutic interventions.
There are three major research areas in the lab:
We employ several techniques to accomplish our research goals, including (presented in the figure with representative results)
Past and present personnel and collaborators
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