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  • Mallikarjuna Reddy Pabbidi, DVM, PhD

    PabbidiMalikarjuna_PhaF5.jpgAssistant Professor
    Office: G328
    Phone:(601)984-2320
    E-mail: mpabbidi@umc.edu

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    Research interests

    • Cerebral vascular smooth muscle electrophysiology
    • Calcium imaging
    • Vascular reactivity studies

    Current research

    Myogenic responsiveness and autoregulation of renal and cerebral blood flow is altered in hypertension and diabetes. These conditions are the major risk factors for the development of cerebral vascular dysfunction, stroke, and chronic kidney disease. Loss of myogenic tone contributes to increased transmission of pressure to the cerebral capillaries, breakdown of the blood brain barrier, cerebral edema and neurological damage following ischemia or trauma. Impaired auto regulation of renal blood flow leads to glomerulosclerosis, proteinuria and chronic kidney disease. My lab is interested in identifying the role of altered ion-channel activity of vascular smooth muscle (VSM) cells in cerebral and renal vasculature in Fawn Hooded Hypertensive (FHH) rats.

    The FHH rat is a good genetic model system in which autoregulation of renal and cerebral blood flow is impaired, and we have developed a congenic strain of FHH.1BN rats in which a small region of chromosome 1 from BN rats is transferred into the FHH genome and autoregulation is restored. My lab utilizes enzymatically isolated VSM cells to perform patch clamp and calcium imaging studies (single channel and whole cell current recording), and, we perform vascular reactivity studies both in vivo and in vitro. We study ion-channels such as calcium-activated potassium, voltage-gated calcium, TRP, and ENaC, in the regulation of vascular tone. My lab also studies the role of second messenger signaling molecules such as PKC, DAG, IP3, etc., in the regulation of these ion-channels.

    Selected publications

    • Wang, Y.G., Ji, X., Pabbidi, M., Samarel, A.M., and Lipsius, S.L., 2009, "Laminin acts via focal adhesion kinase/phosphatidylinositol-3' kinase/protein kinase B to down-regulate beta1-adrenergic receptor signalling in cat atrial myocytes". J Physiol. 587(Pt 3): p. 541-50. PubMedCentral ID: PMC2670079. PubMed link
    • Pabbidi, M.R., Ji, X., Samarel, A.M., and Lipsius, S.L., 2009, "Laminin enhances beta(2)-adrenergic receptor stimulation of L-type Ca(2+) current via cytosolic phospholipase A(2) signalling in cat atrial myocytes". J Physiol. 587(Pt 20): p. 4785-97. PubMedCentral ID: PMC2770147. PubMed link
    • Wang, Y.G., Zima, A.V., Ji, X., Pabbidi, R., Blatter, L.A., and Lipsius, S.L., 2008, "Ginsenoside Re suppresses electromechanical alternans in cat and human cardiomyocytes". Am J Physiol Heart Circ Physiol. 295(2): p. H851-9. PubMedCentral ID: PMC2519214. PubMed link
    • Pabbidi, R.M., Yu, S.Q., Peng, S., Khardori, R., Pauza, M.E., and Premkumar, L.S., 2008, "Influence of TRPV1 on diabetes-induced alterations in thermal pain sensitivity". Mol Pain. 4: p. 9. PubMedCentral ID: PMC2275252. PubMed link
    • Pabbidi, R.M., Cao, D.S., Parihar, A., Pauza, M.E., and Premkumar, L.S., 2008, "Direct role of streptozotocin in inducing thermal hyperalgesia by enhanced expression of transient receptor potential vanilloid 1 in sensory neurons". Mol Pharmacol. 73(3): p. 995-1004. PubMed PMID:18089839. PubMed link
    • Raisinghani, M., Pabbidi, R.M., and Premkumar, L.S., 2005, "Activation of transient receptor potential vanilloid 1 (TRPV1) by resiniferatoxin". J Physiol. 567(Pt 3): p. 771-86. PubMedCentral ID: PMC1474234. PubMed linkĀ