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  • Jian-Xiong Chen, MD

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    Associate Professor
    Office: G325
    Phone: (601) 984-1731 (office) 
                (601) 984-2136 (lab)
    Fax: (601) 984-1637
    E-mail: Jchen3@umc.edu

     

    Research interests

    • Oxidants and angiogenesis
    • Angiogenic factors gene therapy on diabetic impaired angiogenesis
    • Myocardial regeneration and bone marrow/stem cell differentiation

    Current research

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    The long-term goals of my laboratory research are to understand the pathogenesis and identify the intracellular molecular basis that may contribute to abnormal angiogenesis and regeneration, exacerbation of cardiac dysfunction and heart failure, then, to develop novel therapies that can prevent or reverse these devastating diabetic cardiovascular diseases. Specifically, my laboratory research interesting is focused on:

    • The receptor tyrosine kinase (RTK) angiopoietins/Tie-2 system, prolyl hydroxylases-2 (PHD2), apelin/APJ and Notch signaling interactions in the regulation of vascular smooth muscle maturation, capillary growth and regression, cardiac hypertrophy and heart failure. By using genetic modified angiopoietins-2 (Ang-2) null, Notch3 null, conditional knockout of PHD2 diabetic mice model, myocardial ischemia-induced angiogenesis in vivo and in vitro angiogenesis models, we will define: (1) the molecular mechanisms by which hyperglycemia or diabetes disrupt angiopoietins/Tie-2 system and cause vessel immaturation and regression;
    • Their interactive effects with PHD2/HIF-1a signaling and apelin/APJ on myocardial neovessel maturation and angiogenesis; 
    • The mechanisms by which hyperglycemia interferes with pro-inflammatory programme of endothelial cell with a focus on the role of elevated Ang-2;
    • Whether disruption of Jagged1/Notch3 contributes to Ang-2 and diabetes-induced abnormal vascular smooth muscle maturation, vascular progenitor differentiation and facilitate adverse cardiac remodeling and heart failure in diabetes. Identify novel molecular basis as a potential therapeutic target in diabetic cardiac hypertrophy and fibrosis will provide novel approaches to prevent and/or reverse diabetic myocardial ischemia disease.

    Selected publications

    Research articles

    • Chen, JX, Stinnett, A. Disruption of Ang-1/Tie-2 signaling contributes to the impaired myocardial vascular maturation and angiogenesis in type II diabetic mice. Arterioscler Thromb Vasc Biol, 28(9), 1606-13, 2008 PMCID:2584141 PubMed article
    • Chen, JX, Stinnett, A. Critical role of the NADPH oxidase subunit p47phox on vascular TLR expression and neointimal lesion formation in high-fat diet-induced obesity. Lab Invest, 88(12), 1316-28, 2008 PMCID:2584141 PubMed article
    • Chen, JX, Stinnett, A. Ang-1 gene therapy inhibits hypoxia-inducible factor-1alpha (HIF-1alpha)-prolyl-4-hydroxylase-2, stabilizes HIF-1alpha expression, and normalizes immature vasculature in db/db mice. Diabetes, 57(12), 3335-43, 2008 PMCID:2584141 PubMed article
    • Chen, JX, Zeng, H, Tuo, QH, Yu, H, Meyrick, B, Aschner, JL. NADPH oxidase modulates myocardial Akt, ERK1/2 activation, and angiogenesis after hypoxia-reoxygenation. Am J Physiol Heart Circ Physiol, 292(4), H1664-74, 2007 PMCID:2383323 PubMed article
    •  Li, L., Zeng, H., and Chen, J. X. (2012) Apelin-13 increases myocardial progenitor cells and improves repair of post-myocardial infarction, American journal of physiology. Heart and circulatory physiology. PubMed article
    • Zeng, H., Li, L., and Chen, J. X. (2012) Overexpression of angiopoietin-1 increases CD133+/c-kit+ cells and reduces myocardial apoptosis in db/db mouse infarcted hearts, PloS one 7, e35905. PubMed article 
    • Chen, J. X., Tuo, Q., Liao, D. F., and Zeng, H. (2012) Inhibition of protein tyrosine phosphatase improves angiogenesis via enhancing Ang-1/Tie-2 signaling in diabetes, Experimental diabetes research 2012, 836759. PubMed article
    • Chen, J. X., Zeng, H., Reese, J., Aschner, J. L., and Meyrick, B. (2012) Overexpression of angiopoietin-2 impairs myocardial angiogenesis and exacerbates cardiac fibrosis in the diabetic db/db mouse model, American journal of physiology. Heart and circulatory physiology 302, H1003-1012. PubMed article
    • Tuo, Q. H., Xiong, G. Z., Zeng, H., Yu, H. D., Sun, S. W., Ling, H. Y., Zhu, B. Y., Liao, D. F., and Chen, J. X. (2011) Angiopoietin-1 protects myocardial endothelial cell function blunted by angiopoietin-2 and high glucose condition, Acta pharmacologica Sinica 32, 45-51. PubMed article