My laboratory is interested in determining factors that lead to kidney disease during hypertension (high blood pressure) and identifying new targets for the treatment of these diseases.Previous work has shown that production of nitric oxide (NO) is decreased in chronic kidney disease, and this contributes to cardiovascular risk and to further progression of kidney damage. Therefore, interventions that can restore NO production are likely to reduce the cardiovascular complications of CKD as well as slow the rate of progression of renal injury.Relaxin, a hormone that is increased in normal pregnancy, has been shown to cause vasodilation and increase renal blood flow via increased NO production.In addition, relaxin is also anti-fibrotic and may therefore improve kidney structure in disease states.The current goal of the laboratory is to test the therapeutic potential of relaxin in rodent models of kidney disease, specifically focusing on the effects of relaxin on the renal endothelinーNO pathway. We use whole animal and molecular approaches including acute and chronic measurements of blood pressure and renal function and measures of protein abundance and activity.
2500 North State Street
Jackson, MS 39216
General Information: 601-984-1000
Patient Appointments: 888-815-2005