http://youtu.be/Uxk4Dmh1NIIMatch DayTomorrow. Every Day.The Manning Family Fund for a Healthier Mississippi
  • Jeffrey A. Love, PhD

    love_jeffery.jpg

    Associate Professor
    Office: North Wing, N435
    Phone:(601) 984-1621
    E-mail: JLove@umc.edu

     

    Research interest

    • Autonomic control of gastrointestinal function

    Current research

    Neural control of pancreatic secretion

    The long-range goals of our research are to 1) understand how the various branches of the autonomic nervous system regulate pancreatic endocrine and exocrine secretion, and 2) to study the role of the pancreatic innervation in the etiology and/or pathophysiology of acute and chronic pancreatitis and diabetes mellitus.

    The electrical properties of pancreatic neurons, pharmacology and plasticity of synaptic transmission, and noradrenergic transmission were characterized in isolated pancreatic ganglia using intracellular recordings combined with immunohistochemistry, HPLC, and measurements of [3H] norepinephrine release. Cholinergic, adrenergic, and non-adrenergic, non-cholinergic synaptic transmission at the neuroeffector junctions between pancreatic neurons and acini were characterized using immunohistochemistry, and measurements of nerve-stimulated amylase secretion in isolated pancreatic lobules. Primary cultures of adult pancreatic neurons were demonstrated to retain the neurochemical profile and electrical properties observed in neurons from intact ganglia while forming functional cholinergic synapses.

    Future studies of the pancreatic innervation will focus on (1) short- and long-term synaptic plasticity at individual synapses in pancreatic ganglia and in cultured pancreatic neurons, (2) defining the morphology, electrical properties, and synaptic potentials of pancreatic neurons innervating specific targets (acini, islets, ducts), (3) identifying the sources and signaling pathways of inhibitory neurotransmitters in pancreatic ganglia, (4) local reflex control of ganglionic transmission by enteric and post-ganglionic sympathetic neurons, (5) patch-clamp recordings of ionic currents regulating the excitability of acutely isolated pancreatic neurons and the effects of neurotransmitters on these currents, and (6) neuroimmune interactions in ganglia, acini, ducts, and islets during acute and chronic pancreatitis, and diabetes mellitus.

    Selected publications

    • Love, J. A., Yi, E., and Smith, T. G. (2007) Autonomic pathways regulating pancreatic exocrine secretion, Autonomic neuroscience : basic & clinical 133, 19-34. MedPub article 
    • Yi, E., and Love, J. A. (2005) Alpha-adrenergic modulation of synaptic transmission in rabbit pancreatic ganglia, Autonomic neuroscience : basic & clinical 122, 45-57. PubMed article
    • Yi, E., and Love, J. A. (2005) Short-term synaptic plasticity in rabbit pancreatic ganglia, Autonomic neuroscience : basic & clinical 119, 36-47. PubMed article 
    • Yi, E., Smith, T. G., and Love, J. A. (2005) Noradrenergic innervation of rabbit pancreatic ganglia, Autonomic neuroscience : basic & clinical 117, 87-96. PubMed article 
    • Yi, E., Smith, T. G., Baker, R. C., and Love, J. A. (2004) Catecholamines and 5-hydroxytryptamine in tissues of the rabbit exocrine pancreas, Pancreas 29, 218-224. PubMed article 
    • Love, J. A. (2000) Electrical properties and synaptic potentials of rabbit pancreatic neurons, Autonomic neuroscience : basic & clinical 84, 68-77. PubMed article 
    • Love, J. A., Szebeni, K., and Smith, T. G. (2000) Role of adrenergic receptors in veratridine-stimulated amylase secretion from rabbit pancreatic lobules, Pancreas 20, 177-183. PubMed article 
    • Love, J. A., Szebeni, K., and Smith, T. G. (1999) Veratridine-stimulated amylase secretion from rabbit pancreatic lobules: role of cholinergic and noncholinergic receptors, Pancreas 19, 231-238. PubMed article 
    • Love, J. A., and Szebeni, K. (1999) Histochemistry and electrophysiology of cultured adult rabbit pancreatic neurons, Pancreas 18, 65-74. PubMed article 
    • Love, J. A., and Szebeni, K. (1999) Morphology and histochemistry of the rabbit pancreatic innervation, Pancreas 18, 53-64. PubMed article 
    • Love, J. A., Richards, N. W., Owyang, C., and Dawson, D. C. (1998) Muscarinic modulation of voltage-dependent Ca2+ channels in insulin-secreting HIT-T15 cells, The American journal of physiology 274, G397-405. PubMed article