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  • Susan Warren, PhD

    Warren, SusanProfessor
    Office: R719
    Phone: (601) 984-1671
    Lab: R717; Phone: (601) 984-1660
    Fax: (601) 984-1655
    E-mail: swarren@umc.edu

    Research interests

    Visually impaired persons 'understand' their environment by stroking their finger tips across the surface of an object to be identified. Object features such as size, shape, surface textures can be extracted by the interaction of the skin and the object's surface. Development of efficient tactile substitution devices depends on further investigations focusing on somatosensory signal processing. My research interest is centered on studying the fine details of the sense of touch and the perception of complex spatio-temporal patterns applied to the skin. The goal of this laboratory is to gain a better understanding of how a touch - such as a tap, pressure, vibration, or motion - applied to a specific body part is localized, identified and appreciated. This is accomplished by studying the physiologic properties and morphologic connections of groups of neurons located in the thalamus, cortex or brainstem that respond to tactile stimuli. My experimental protocol utilizes animal models and a multidisciplinary approach based on neuroanatomical and electrophysiological techniques and a behavioral paradigm. In addition, my interest focuses on the integration of these sensory signals with motor centers and pathways and their role in evoking stereotyped behaviors.

    Selected publications

    • Gardner, E.P., Hamalainen, H.A., Warren, S., Davis, J.H., and Young, W. (1984) Somatosensory evoked potentials (SEPs) and cortical single unit responses elicited by mechanical tactile stimuli in awake monkeys. Electroenceph. Clin. Neurophysiol. 58:537-552.
    • Hamalainen, H.A., Warren, S., and Gardner, E.P. (1985) Differential sensitivity to air puffs on human hairy and glabrous skin. Somatosensory Res. 2:281-302.
    • Warren, S., Keiahan, A.M., and Pubols, B.H. Jr. (1986) The somatosensory thalamus of the raccoon: properties of single neurons responsive to light mechanical stimulation of the forepaw. J. Neurosci. 6:308-317.
    • Warren, S., Hamalainen, H.A., and Gardner, E.P. (1986) Objective classification of motion and direction sensitive neurons in primary somatosensory cortex of awake monkeys. J. Neurophysiol. 56:598-622.
    • Warren, S., Hamalainen, H.A., and Gardner, E.P. (1986) Coding of spatial period of gratings rolled across the receptive fields of somatosensory cortical neurons in awake monkeys. J. Neurophysiol. 56:623-639.
    • Gardner, E. P., Hamalainen, H.A., Palmer, C.l., and Warren, S. (1992) Simulation of motion on the skin: V. Effect of stimulus temporal frequency on the representation of moving bar patterns in primary somatosensory cortex of monkeys. J. Neurophysiol., 67:37-63.
    • May, P.J., and Warren, S. (1993) Ultrastructure of macaque ciliary ganglion. J. Neurocytol., 22:1073-1095.
    • May, PJ, Warren, S, Chen, BZ, Richmond, FJR, and Olivier, E. (2002) Midbrain reticular formation circuitry subserving gaze in the cat. Annals of New York Academy. 956:405-408.
    • Lohmeier, TE, Lohmeier, JR, Warren, S, May PJ, and Cunningham, TJ. (2002) Sustained activation of the central baroreceptor pathway in angiotensin hypertension. Hypertension. 39:550-556
    • Lohmeier, TE, Warren, S, and Cunningham, TJ. (2003) Sustained activation of the central baroreflex pathway in obesity hypertension. Hypertension. 41:96-102.
    • Lohmeier, TE, Hildebrandt, DA, Warren, S, May, PJ, and Cunningham, TJ. (2005) Recent insights into the interactions between the baroreflex and the kidneys in hypertension. Am J Physiol Regul Integr Comp Physiol. 288:R828-R836.
    • Perkins, E, Warren, S, Lin, R, C-S, and May, PJ (2006) Projections of Somatosensory Cortex and Frontal Eye Fields Upon Incertotectal Neurons in the Cat. Anatomical Record A, 288:1310-1329.
    • Warren, S, Waitzman, DM, and May, PJ (2008) Anatomical Evidence for Interconnections Between Central Mesencephalic Reticular Formation and Cervical Spinal Cord in the Cat and Macaque. Anatomical Record A, 291:141-160.
    • Zhou, L, Warren, S, and May, PJ (2008) The Feedback Circuit Connecting the Central Mesencephalic Reticular Formation and the Superior Colliculus in the Macaque Monkey: Tectal Connections. Exp. Brain Research Online: 14 June 2008
    • Perkins, E, Warren, S, and May, PJ (2009) The Mesencephalic Reticular Formation as a Conduit for Primate Collicular Gaze Control: Tectal Inputs to Neurons Targeting the Spinal Cord and Medulla. Anatomical Record A Online: 30 July 2009. 292(8):1162-1181.
    • Wang, N, Warren, S, and May, PJ (2010) The macaque midbrain reticular formation sends side-specific feedback to the superior colliculus. Exp. Brain Research Online: 26 November 2009. 201:701-717.

    Book chapters

    • Pubols, B.H. Jr., and Warren, S. (1985) Information processing within the raccoon somatosensory system. In: Development. Organization and Processing in Somatosensory Pathways. M.J. Rowe and W.D. Willis, eds. Alan R. Liss, Inc., N.Y. pp. 183-189.
    • Warren, S., Hamalainen, H.A., Palmer, C.l., and Gardner, E.P. (1991) Transformation of Spatio-temporal Information by Somatosensory Neural Networks. In: Werner-Gren International Symposium Series: Information Processing in the Somatosensory System. O. Franzen and J. Westman, eds. Macmillian Press, London. pp.

    Selected Abstracts

    • May, PJ, Perkins, and Warren, S (2005) The macaque central mesencephalic reticular formation as an intermediary in tectal gaze control. Gordon Research Conference.
    • Perkins, E, May, PJ, and Warren, S (2005) Distribution of Central Mesencephalic Reticular Formation Output Neurons Projecting to Brainstem Gaze Centers. Program No. 858.3. 2005 Abstract Viewer/Itinerary Planner, Washington, DC. Society for Neuroscience, 2005. Online
    • May, PJ, Perkins, Zhou, L, and Warren, S (2005) Macaque Central Mesencephalic Reticular Formation Connections Underlying Collicular Control of Gaze. Program No. 858.4. 2005 Abstract Viewer/Itinerary Planner, Washington, DC: Society for Neuroscience, 2005. Online.
    • Zhou, L, Warren, S, and May, PJ (2006) Projections of the central mesencephalic reticular formation in the macaque. Program No. 139.1. 2006 Neuroscience Meeting Planner. Atlanta, GA: Society for Neuroscience, 2006. Online.
    • Warren, S, Perkins, E, and May, PJ (2007) The Pattern of Central Mesencephalic Formation Neuronal Terminations in Brainstem Gaze Centers. Gordon Research Conference
    • Wang, N, Warren, S, and May, PJ (2008) The macaque central mesencephalic reticular formation sends inhibitory feedback to ipsilateral tectal neurons. Program No. 263.4. 2008 Neuroscience Meeting Planner. Washington, DC: Society for Neuroscience, 2008. Online.
    • Warren, S, Zhou, L, and May, PJ (2008) Sources of input to the central mesencephalic reticular formation in Macaque Monkeys. Program No. 263.3. 2008 Neuroscience Meeting Planner. Washington, DC: Society for Neuroscience, 2008. Online.
    • Klier, EM, Meng, H, Warren, S, May, PJ, and Angelaki DE (2008) Anatomy and physiology of thalamic neurons subserving saccades, pursuit and vestibular whole-body rotation. Program No. 855.19. 2008 Neuroscience Meeting Planner. Washington, DC: Society for Neuroscience, 2008. Online.
    • Warren, S, Zhou, L, and May, PJ (2009) The Origin of Inputs to the Monkey Central Mesencephalic Reticular Formation (cMRF). Program No. 832.2. 2009 FASEB Meeting Planner. New Orleans, LA.
    • Wang, N, Warren, S, and May, PJ (2009) The Macaque Midbrain Reticular Formation Sends Different Types of Feedback to Each Side of the Superior Colliculus. Program No. 832.3. 2009 FASEB Meeting Planner. New Orleans, LA.
    • Wang, N, Warren, S, and May, PJ (2009) Ultrastructural evidence the central mesencephalic reticular formation may depress omnipause neuron activity for tectally evoked saccades. Program No. 851.9. 2009 Neuroscience Meeting Planner. Chicago, IL.: Society for Neuroscience, 2009. Online.
    • Warren, S, and May, PJ (2010) Targets of the tectal projections to the oculomotor nucleus. Program No. 894.10. 2010 Neuroscience Meeting Planner. San Diego, CA: Society for Neuroscience, 2010. Online.