Faculty, Students and Staff

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  • Paul J. May, PhD

     may, paul.jpg

    Professor
    Assistant Professor of Ophthalmology
    Assistant Professor of Neurology
    Office: R720
    Phone: (601) 984-1662
    Lab: R717; Phone: (601) 984-2646
    Fax: (601) 984-1655
    E-mail: pmay@umc.edu

    Education

    • AB - Brown University, Providence, R.I. 1976, biology and English literature
    • PhD - Duke University, Durham, N.C. 1983, anatomy. Dissertation title: "The Motor Colliculus: Its Morphology and Inputs." Thesis adviser: William C. Hall, PhD
    • Postdoctoral fellow - Department of Physiology & Biophysics, New York University Medical Center, New York, NY, 1983-86. Mentor: Robert Baker, PhD

    Research and teaching interests

    The general experimental theme of the laboratory is the study of gaze control utilizing anatomical and, in some cases, physiological methods. Dual input-output labeling techniques have been pioneered in this laboratory to support this investigation on the light and electron microscopic level. Students joining the lab can take advantage of opportunities to learn: neuroanatomical tracer techniques, immunohistochemistry, sterile surgery, electron microscopy and post-embedding immunohistochemical localization. There are ongoing investigations in a number of areas concerning gaze control:

    • Control of movements of the eyes and head by the superior colliculus. Both the input-output relationships of superior colliculus and the relationship of collicular projections to cell populations in the horizontal and vertical gaze centers have been and are being studied. The emphasis is on determining the morphology and laminar location of relevant collicular neurons and their synaptic relationships, both within the superior colliculus and between collicular axons and target neurons.
    • Neuronal circuitry controlling the lens and pupil is being investigated. Neuroanatomical tracers have been used to determine the circuits controlling the pupillary light reflex, and are being applied to identify the circuits controlling the near reflex components, i.e., ciliary muscle for lens accommodation, medial rectus muscle for vergence and sphincter pupillae muscle for pupillary constriction.
    • Determination of the premotor circuitry underlying the blink reflex. The act of blinking is a simple reflex activity that has become important in various learning paradigms and has clinical relevance as well. However, the circuits that support this reflex are poorly understood. This investigation is utilizing dual labeling of inputs and outputs to define blink circuits at the light and electron microscopic level.

    The PI is trained to teach in all components of the Neurobiology and Anatomical Sciences curriculum. Current teaching responsibilities are chiefly in Medical Histology. The PI has been the thesis adviser for several PhD candidates and one MS candidate.

    Grants

    • NIH Biological Systems Training Grant 1977-80
    • NEI Post Doctoral Fellowship (EY05689) 1983-86. Colliculoreticular Relationships Underlying Eye Movement. Mentor: Robert Baker, PhD
    • NEI First Award (EY07166) 1987-92. Neuronal Circuitry Controlling the Lens and Pupil ($219,941)
    • NEI Small Inst. Prog. Coinvest. (EY08440) 1989-90
    • NEI RO1 Grant (EY09762) 1993-97. Neuronal Circuitry Controlling the Extrinsic Eye Muscles ($221,426)
    • Benign Essential Blepharospasm Research Foundation Grant 1998-99
    • Physiology of Blink Circuits in an Awake Behaving Monkey ($20,484- Direct). Co-PI, PI - Susan Warren, University of Mississippi Medical Center
    • NIH RO1 Grant (NS37931) 2000-04. Physiology and Anatomy of Zona Incerta ($598,000- Direct). Co-PI; PI - Rick C.S. Lin, PhD, University of Mississippi Medical Center
    • University of Mississippi Medical Center Intramural Grant 2001-02. Alzheimer's Neurotoxicity in the Edinger-Westphal Nucleus ($12,023)
    • NSF Grant (IBN-013954) 2002-05. Synaptic Organization of the Primate Pulvinar ($81,505 - Direct). Co-PI, PI - Martha Bickford, PhD, University of Louisville
    • NEI RO1 Grant (EY014263) 2003-13. Midbrain Circuitry for Neuronal Control of Gaze ($900,000 - Direct)
    • NIH RO1 Grant (DC004260) 2005-09. Neural Mechanisms of Vestibular Function. Co-PI; PI - Dora Angelaki, PhD, Washington University ($68,663 - Direct)

    Publications and papers

    • May, Paul J. and William C. Hall. (1984) Relationships between the nigrotectal pathway and the cells of origin of the predorsal bundle. Journal of Comparative Neurology 226: 357-376.
    • Lin, Chia-Sheng, Paul J. May and William C. Hall. (1984) Nonintralaminar thalamostriatal projections in the gray squirrel (Sciurus carolinensis) and tree shrew (Tupia glis). Journal of Comparative Neurology 230: 33-46.
    • May, Paul J. and William C. Hall. (1986) The sources of the nigrotectal pathway. Neuroscience 19: 159-180.
    • May, Paul J. and William C. Hall. (1986) The cerebellotectal pathway in the grey squirrel. Experimental Brain Research 65: 200-212.
    • May, Paul J., Harriet Baker, Pierre-Paul Vidal, Robert F. Spencer and Robert Baker. (1987) Morphology and distribution of serotoninergic and oculomotor internuclear neurons in the cat midbrain. Journal of Comparative Neurology 266: 150-170.
    • Vidal, Pierre-Paul, Paul J. May and Robert Baker. (1988) Synaptic organization of the tectal-facial pathways in the cat. I. Synaptic potentials following collicular stimulation. Journal of Neurophysiology 60: 769-797.
    • Porter, John D., Leigh Ann Burns and Paul J. May. (1989) The morphological substrate for eyelid movements: Innervation and structure of primate levator palpebrae superioris and orbicularis oculi muscles. Journal of Comparative Neurology 287: 64-81.
    • May, Paul J., Pierre-Paul Vidal and Robert Baker. (1990) Synaptic organization of the tectal-facial pathways in the cat. II. Synaptic potentials following midbrain tegmentum stimulation. Journal of Neurophysiology 64: 381-402.
    • May, Paul J., Rosi Hartwich-Young, Jon Nelson, David L. Sparks and John D. Porter. (1990) Cerebellotectal pathways in the macaque: Implications for collicular generation of saccades. Neuroscience 36: 305-324.
    • Haines, Duane E., Paul J. May and Espen Dietrichs. (1990) Neuronal connections between the cerebellar nuclei and hypothalamus in Macaca fascicularis: Cerebello-visceral circuits. Journal of Comparative Neurology 299: 106-122.
    • May, Paul J., John D. Porter and Paul Gamlin. (1992) Interconnections between the cerebellum and midbrain near response regions. Journal of Comparative Neurology 315: 98-116.
    • May, Paul J. and John D. Porter. (1992) The laminar distribution of macaque tectobulbar and tectospinal neurons. Visual Neuroscience 8: 257-76.
    • May, Paul J. and Susan Warren. (1993) Ultrastructure of the macaque ciliary ganglion. Journal of Neurocytology 22: 1073-1095.
    • Sun, Wensi and Paul J. May. (1993) Organization of the extraocular and preganglionic motoneurons supplying the orbit in the lesser galago. Anatomical Record 237: 89-103.
    • Sun, Wensi, Jonathan T. Erichsen and Paul J. May. (1994) NADPH-Diaphorase reactivity in ciliary ganglion neurons: A comparison of distributions in the pigeon, cat and monkey. Visual Neuroscience 11: 1027-1031.
    • Baker, Robert S., Michael W. Stava, Kevin R. Nelson, Paul J. May, Mark D. Huffman, John D. Porter. (1994) Aberrant reinervation of facial musculature in a subhuman primate: A correlative analysis of eyelid kinematics, muscle synkinesis and motoneuronal localization. Neurology 44: 2165-2173.
    • May, Paul J., Wensi Sun and William C. Hall. (1997) Reciprocal connections between the zona incerta and the pretectum and superior colliculus of the cat. Neuroscience 77: 1091-1114.
    • Olivier, Etienne, John D. Porter and Paul J. May. (1998) Comparison of the distribution and somatodendritic morphology of tectotectal neurons in the cat and monkey. Visual Neuroscience 15: 903-922.
    • May, Paul J. and John D. Porter. (1998) The distribution of primary afferent terminals from the eyelids of macaque monkeys. Experimental Brain Research 123: 368-381.
    • Chen, Bingzhong and Paul J. May. (2000) The feedback circuit connecting the superior colliculus and central mesencephalic reticular formation: A direct morphological demonstration. Experimental Brain Research 131: 10-21.
    • Erichsen, Jonathan T. and Paul J. May. (2002) The pupillary and ciliary components of the cat Edinger-Westphal nucleus: A trans-synaptic transport Investigation. Visual Neuroscience 19: 15-29.
    • Chen, Bingzhong and Paul J. May. (2002) Premotor control of eyelid movements in conjunction with vertical saccades in the cat: The rostral interstitial nucleus of the medial longitudinal fasciculus. Journal of Comparative Neurology 450: 183-202.
    • Lohmeier, Thomas E., Justin R. Lohmeier, Susan Warren, Paul J. May and J. Thomas Cunningham. (2002) Sustained activation of the central baroreceptor pathway in angiotensin hypertension. Hypertension 39: 550-6.
    • Baldauf, Zsolt B., Ranida D. Chomsung, W. Breckinridge Carden, Paul J. May and Martha E. Bickford. (2004) Ultrastructural analysis of projections to the cat pulvinar nucleus I: Middle suprasylvan gyrus (areas 5 and 7). Journal of Comparative Neurology 485: 87-107.
    • Baldauf, Zsolt B., Siting Wang, Ranida D. Chomsung, Paul J. May and Martha E. Bickford. (2004) Ultrastructural analysis of projections to the cat pulvinar nucleus II. Pretectum. Journal of Comparative Neurology 485: 108-126.
    • McHaffie, John G., Huai Jiang, Paul J. May, Veronique Coizet, Paul G. Overton, Barry E. Stein, and Peter Redgrave (2006) A direct projection from superior colliculus to substantia nigra pars compacta in the cat. Neuroscience 138: 221-234.
    • Perkins, E., S. Warren, R.C.-S. Lin and P.J. May (2006) Projections of somatosensory cortex and frontal eye fields upon incertotectal neurons in the cat. Anatomical Record 288A: 1310-1329.
    • Chen, Bingzhong and Paul J. May. (2007) Premotor control of eyelid movements in conjunction with vertical saccades in the cat: The interstitial nucleus of Cajal. Journal of Comparative Neurology 500: 676-692.
    • Takahashi, Katsumasa, Yong Gu, Paul J. May, Shawn D. Newlands, Gregory C. DeAngelis, Dora E. Angela (2007) Multimodal coding of three-dimensional rotation and translation in area MSTd: Comparison of visual and vestibular selectivity. Journal of Neuroscience 27: 9742-9756.
    • Meng, Hui, Paul J. May, J. David Dickman and Dora E. Angelaki (2007) Vestibular signals in primate thalamus. Journal of Neuroscience 27: 13590-13602.
    • May, Paul J., Anton J. Reiner and Andrey E. Ryabinin (2008) Comparison of the distributions of urocortin containing and cholinergic neurons in the perioculomotor midbrain of the cat and macaque. Journal of Comparative Neurology 507: 1300-1316.
    • Warren, Susan, David M. Waitzman and Paul J. May (2008) Anatomical evidence for interconnections between the central mesencephalic reticular formation and cervical spinal cord in the cat and macaque. Anatomical Record 291: 141-160.
    • Wang, Niping and Paul J. May (2008) Peripheral muscle targets and central projections of the mesencephalic trigeminal nucleus in macaque monkeys. Anatomical Record 291: 974-987.
    • Zhou, Lan, Susan Warren and Paul J. May (2008) The feedback circuit connecting the central mesencephalic reticular formation and the superior colliculus in the macaque monkey: Tectal connections. Experimental Brain Research 189:485-96.
    • May, Paul J., John G. McHaffie, Terrence R. Stanford, Huai Jiang, M. Gabriela Costello, Veronique Coizet, Lauren M. Hayes, Suzanne N. Haber and Peter Redgrave (2009) Tectonigral projections in the primate: A pathway for pre-attentive sensory input to midbrain dopaminergic neurons. European Journal of Neuroscience 29: 575-587.
    • Perkins, Eddie, Susan Warren and Paul J. May (2009) The mesencephalic reticular formation as a conduit for primate collicular gaze control: Tectal inputs to neurons targeting the spinal cord and medulla. Anatomical Record 292: 1162-1181.
    • Wang, Niping, Susan Warren and Paul J. May (2010) The macaque midbrain reticular formation sends side-specific feedback to the superior colliculus. Experimental Brain Research 201: 701-717.
    • Zimmerman, Lars, Paul. J. May, Angel M. Pastor, Johannes Streicher, Roland Blumer (2011) Evidence that the extraocular motor nuclei innervate monkey palisade endings. Neuroscience Letters 489: 89-93.

    Book chapters

    • Hall, William C. and Paul J. May. The anatomical basis for sensorimotor transformations in the superior colliculus. In: Contributions to Sensory Physiology, edited by W.D. Neff, Academic Press, New York, Vol. 8: 1-40 (1983).
    • May, Paul J, William C. Hall, John D. Porter and Sharleen T. Sakai. The comparative anatomy of nigral and cerebellar control over tectally initiated orienting movements. In: Role of the Cerebellum and Basal Ganglia in Voluntary Movement, edited by N. Mano, I. Hamada and M.R. DeLong, Elsevier, Amsterdam, pp. 221-231. 
    • May, Paul J. and James J. Corbett. Visual Motor Systems. In: Fundamental Neuroscience, Textbook edited by D. E. Haines, Churchill Livingstone, New York, pp. 399-426 (1997). 
    • Mihailoff, Gregory A., Paul J. May and Duane E. Haines. The Midbrain. In: Fundamental Neuroscience, Textbook edited by D. E. Haines, Churchill Livingstone, New York, pp. 177-188 (1997). 
    • May, Paul J. and Susan Warren. (2000) Brainstem Pathways Controlling Lid Closure. In: BenignEssentialBlepharospasmNewsletter. Vol. 19, No. 2, pp. 3-4. 
    • May, Paul J. (2001) Superior Colliculus. In: The Encyclopedia of Neurological Sciences. Edited by M.J. Aminoff and R.B. Daroff, Academic Press.   
    • May, Paul J., Robert G. Baker and Bingzhong Chen (2002) The Eyelid Levator Muscle: Servant of Two Masters. Movement Disorders 17, pp.S4-S7. 
    • May, Paul J. and James J. Corbett. (2001) Visual Motor Systems. In Fundamental Neuroscience, 2'nd Edition, Textbook edited D. E. Haines, Churchill Livingstone, New York, pp. 399-426. 
    • Mihailoff, Gregory A., Paul J. May and Duane E. Haines. (2001) The Midbrain. In: Fundamental Neuroscience, 2'nd Edition, Textbook edited. D. E. Haines, Churchill Livingstone, New York, pp. 177-188. 
    • May, Paul J., Susan Warren, Bingzhong Chen, Frances J.R. Richmond and Etienne Olivier (2002) Midbrain Reticular Formation Circuitry Subserving Gaze in the Cat. In: Neurobiology of Eye Movements. Annals of the New York Academy of Sciences Vol. 956, Edited by H.J. Kaminsky and R.J. Leigh. New York, pp.405-408. 
    • May, Paul J. (2003) Superior Colliculus. In: Encyclopedia of Neurological Sciences, Ed: Aminoff, M. and Daroff, R, Vol. 4, Academic Press, San Diego, pp. 443-6. 
    • Piletz, John E., Paul J. May, Gong Wang and Hong Zhu (2003) Agmatine Crosses the Blood-Brain Barrier. In: Annals of the New York Academy of Sciences Vol 1009, pp. 64-74.  
    • Lohmeier, Thomas E., Drew A. Hildebrandt, Susan Warren, Paul J. May and J. Thomas Cunningham (2005) New Insights into the Interactions Between the Baroreflex and the Kidneys in Hypertension. In: American Journal of Physiology: Regulatory, Integrative and Comparative Physiology 288: R828-R836.  
    • May, Paul J. (2006) The Mammalian Superior Colliculus: Laminar Structure and Connections. In: Neuroanatomy of the Oculomotor System. Ed: Jean Battner-Ennever, Progress in Brain Research, Vol. 151, Elsevier, Amsterdam, pp. 321-78.  
    • May, Paul J. and James J. Corbett. (2006) Visual Motor Systems. In: Fundamental Neuroscience, 3'd Edition, Textbook edited by D.E. Haines, Churchill Livingstone, New York, pp. 454-472.
    • Mihailoff, Gregory A., Duane E. Haines and Paul J. May. (2006) The Midbrain. In: Fundamental Neuroscience, 3'd Edition, Textbook edited by D.E. Haines, Churchill Livingstone, New York, pp. 196-208.  
    • May, Paul J., Wensi Sun and Jonathan T. Erichesen (2008) Defining the Pupillary Component of the Perioculomotor Preganglionic Population within a Unitary Primate Edinger-Westphal Nucleus. In: Using Eye Movements as an Experimental Probe of Brain Function, C. Kennard & R.J. Leigh (Eds) Progress in Brain Research Vol. 171, pp. 97-106

    Recent abstracts

    • May, P.J. and E. Perkins, L. Zhou and S. Warren (2005) Macaque Central Mesencephalic Reticular Formation Connections Underlying Collicular Control of Gaze. Soc. Neurosci. Abst. 31.
    • Eisenback, M.A, P.J. May, S. Warren and M.E. Bickford (2005) Synaptic Organization of the Primate Pretectopulvinar Pathway. Soc. Neurosci. Abst. 31:
    • Zhou, L, S. Warren and P.J. May (2006) Projection of the central mesencephalic reticular formation in the macaque. Soc. Neurosci. Abst. 32.
    • Meng, H., P.J. May, J.D. Dickman and D. Angelaki (2006) Neural response properties and anatomical origins of vestibular responses in the primate thalamus. Soc. Neurosci. Abst. 32.
    • McHaffie, J.G., H. Jiang, T.R. Stanford, M.G. Costello, P. Redgrave, V. Coizet, and P.J. May (2006) The subthalamic nucleus receives afferents from the superior colliculus in cats and macaque monkeys. Soc. Neurosci. Abst. 32.
    • May, P.J., J.G. McHaffie, H. Jiang, T.R. Stanford, M.G. Costello, S.N. Haber, V. Coizet, and P. Redgrave (2006) Projections from the superior colliculus to the substantia nigra pars compacta in a primate. Soc. Neurosci. Abst. 32.
    • May, P.J., L. Zhou, E. Perkins, R.C.-S. Lin, P. Redgrave, T.R. Stanford and J.G. McHaffie (2007) Looped circuitry modulating tectally directed gaze behavior. 17'th NCMS Satellite Symposium.
    • May, P.J., A.J. Reiner and A.E.Ryabinin (2007) Urocortin positive and preganglionic perioculomotor populations in the cat and macaque. Soc. Neurosci. Abst. 33.
    • Wang, N., S. Warren and P.J. May (2008) The macaque central mesencephalic reticular formation sends inhibitory feedback to ipsilateral tectal neurons. Soc. Neurosci. Abst. 34.
    • Warren, S., L. Zhou and P. J. May (2008) Sources of input to the central mesencephalic reticular formation in macaque monkeys. Soc. Neurosci. Abst. 34.