Professor, Department of Pharmacology and ToxicologyDirector, Cancer Genetics ProgramPhD, Plant Pathology, 1991, Washington State University, Pullman, WAPostdoc, 1991-94, Microbiology, Washington State University, Pullman
Contact information2500 N State St., Room G651-3Jackson, MS 39216Phone: (601) 815-6849E-mail: firstname.lastname@example.org
My laboratory has been focusing on understanding of epigenetic regulation of genes involved in tumorigenesis and chemoresistance.
It is well known that only a small portion of the human genome codes for proteins; however, over 50% of the genome is actively transcribed into non-protein-coding RNAs which can be divided into at least two large groups based on their lengths: 1) small non-coding RNAs and 2) long non-coding RNAs (lncRNAs) with >200 nucleotides in length, including long intervening non-coding RNAs or large intergenic non-coding RNAs (lincRNAs). MicroRNAs represent a functional and well characterized group of small non-coding RNAs. On the other hand, lncRNAs are much less well characterized. In the past years, we have been actively working on both microRNAs and lncRNAs. For example, we have shown that miR-21 is overexpressed in several types of tumors compared to the matched normal tissues and that more importantly, suppression of miR-21 by a miR-21 inhibitor substantially reduces tumor growth in a xenograft carcinoma mouse model, suggesting that miR-21 is an oncogenic microRNA.
On the other hand, miR-145 functions as a tumor suppressor. In particular, miR-145 plays a critical role in p53-mediated repression of c-Myc. More recently, we have expanded our research on regulation of lncRNAs and their role in tumorigenesis. Therefore, further characterization of these non-coding genes in clinical specimens would help identify whether non-coding RNAs may serve potential biomarkers for high risk patient population. At the same time, this will also provide new insight into molecular mechanisms underlying non-coding RNA-mediated gene regulation, tumor growth and invasion, and chemoresistance. As a result, these studies will benefit cancer patient by providing cancer risk assessment and health management recommendations.
2500 North State Street
Jackson, MS 39216