Associate Director for Basic ScienceProfessor, Department of Microbiology and BiochemistryCancer Genetics Program PhD, Biochemistry, 1981, Kyoto University, JapanPostdoc, 1981-85, University of Arizona Health Science Center
Contact information2500 N State St., Suite G651-07Jackson, MS 39216Phone: (601) 815-8305Fax: (601) 815-6806E-mail: firstname.lastname@example.org
The studies of our laboratory focus on the molecular mechanism of tumor metastasis in breast and prostate cancers. Much of the lethality of malignant neoplasms is attributable directly to their ability to develop secondary growths in organs at a distance from the primary tumor mass. Our group has been working on tumor metastasis suppressor genes including KAI1 and NDRG1and trying to elucidate the roles of these genes in cancer stem-like cells (CSCs), in the context of tumor microenvironment. We are also working on tumor-stromal cells interaction by particularly focusing on Notch signaling, hyaluronic acid and BMP7 (bone morphogenetic protein 7) in bone and brain metastasis. We have recently found that BMP7 secreted from bone stromal cells induces senescence in CSCs by activating p38 MAPK and increasing expression of p21 and NDRG1, indicating that the BMP7-p38-NDRG1 axis plays a critical role in dormancy and recurrence of CSCs in bone and suggests a potential therapeutic utility of BMP7 for recurrent metastatic disease. Due to our discovery, BMP7 was named as the 2011 Molecule of the Year by The International Society for Molecular and Cell Biology and Biotechnology Protocols and Research. The long term goal of this line of research is to construct a molecular map of metastasis cascade signaling, which can eventually lead to identification of better diagnostic markers and therapeutic targets for this devastating disease. Another major focus of our research is tumor metabolism, particularly in lipogenesis, at an early stage of breast cancer. We have recently identified multiple microRNAs and lincRNAs that play critical roles in CSCs of breast cancer and in-depth analysis of these molecules are currently underway.
2500 North State Street
Jackson, MS 39216