Professor, Department of MedicineCancer Genetics ProgramMD, UT Southwestern Medical School, Dallas, TXInternal Medicine (internship/residency), UT Southwestern Medical School, DallasMedical Genetics (fellowship), Johns Hopkins University School of Medicine, Baltimore, MDPostdoc - Molecular Biology & Genetics, Johns Hopkins University School of Medicine, Baltimore
Contact informationGuyton Research Bldg., room G658University of Mississippi Medical Center2500 N. State St.Jackson, MS 29216E-mail: email@example.com
Our laboratory is interested in the role of cell-fate determination in development, homeostasis, and cancer cell transformation; and the associated signaling, transcriptional, and post-transcriptional mechanisms that govern these processes. We focus the Fem1 genes (Fem1a, Fem1b, Fem1c), homologs of the fem-1 gene in the sex-determination pathway of the nematode C. elegans; this pathway in the nematode is a signal transduction/transcriptional regulatory pathway that controls diverse cell-fate decisions, including apoptosis, and has homology to the Hedgehog signaling pathway of flies and mammals.
Fem1b is pro-apoptotic and has been found to be a Wnt and c-Myc target gene in neoplastic intestinal epithelium, and mediates proteasome inhibitor-induced apoptosis of malignant colon cancer cells. Currently we are exploring: the molecular basis of Fem1b regulation in colon cancer cells; the involvement of Fem1b in other epithelial cancers; the interaction of Fem1b with the Gli oncogenes; we are also exploring the utility of Fem1b expression as a biomarker of pathological Wnt signaling in neoplastic epithelium. Fem1a interacts with NF-κB, and we are investigating this interaction in skeletal muscle differentiation and rhabdomyosarcoma development.
In addition, I have a clinical interest in patients with genetic disorders, including hereditary predisposition to cancer, which offers opportunities for patient-oriented research into cancer gene discovery and clinical utility.
2500 North State Street
Jackson, MS 39216