Assistant Professor Molecular Cancer Therapeutics Program MD, 1982, Shanghai Medical College, Fudan University, Shanghai, China Postdoctoral Fellow, 1988-1995, Columbia University, New York, NY
Contact information 2500 N State St, Room G162Jackson, MS 39216Phone: (601) 815-3402E-mail: email@example.com
The research interests in my lab mainly focus on the metabolic control of angiogenesis and its role in cancer and cardiovascular disease. The growth and expansion of a tumor is mainly dependent on angiogenesis, the formation of new capillaries from pre-existing blood vessels. Vascular endothelial growth factor (VEGF) is the most critical regulator in angiogenesis and is commonly over-expressed in the most of tumors, in which tumor cells are under greater oxidative stress than normal cells. We have recently reported that VEGF and its receptors are the important biological markers for breast cancer malignancy and progression, and demonstrated that the paracrine effects (especially angiogenesis) and the autocrine effects (proliferation and migration) of VEGF are involved in promoting breast cancer progression. We also report that alcohol intake or obesity markedly increases tumor growth rate by mechanisms that involve up-regulation of VEGF pathways. Recent insights have shed light onto the interplay between VEGF and Notch signaling in angiogenesis. Clearly, inhibiting tumor angiogenesis can play a key role in cancer prevention and treatment. Our current research projects include: 1) postmenopausal obesity promotes tumor angiogenesis and breast cancer progression; 2) role of exercise-induced circulating angiostatic phenotype in the adipose tissue accumulation and breast cancer progression; 3) mechanisms of alcohol intake in tumor angiogenesis and breast cancer progression; 4) combination of EGCG (a green tea antioxidant) and SU11248 (a selective VEGF receptor inhibitor) to treat cancers including breast cancer; and 5) interplay between VEGF and Notch signaling in tumor angiogenesis and breast cancer progression.
2500 North State Street
Jackson, MS 39216
General Information: 601-984-1000
Patient Appointments: 888-815-2005